ArticleJournal of bacteriology2005
Assimilation of nicotinamide mononucleotide requires periplasmic AphA phosphatase in Salmonella enterica.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Biosynthesis of β-nicotinamide mononucleotide from glucose via a new pathway inFrontiers in microbiology · 2024Article
- Unresolved mystery of cyclic nucleotide second messengers, periplasmic acid phosphatases and bacterial natural competence.Microbial cell (Graz, Austria) · 2024Article
- cAMP competitively inhibits periplasmic phosphatases to coordinate nutritional growth with competence of Haemophilus influenzae.The Journal of biological chemistry · 2023Article
- Integration of the pSLT Plasmid into theJournal of bacteriology · 2020Article
- Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor.Microbial cell factories · 2020Article
- Structural and Functional Characterization of NadR fromMolecules (Basel, Switzerland) · 2020Article
- Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis.Nature chemical biology · 2020Article
- Niacin-mediated Gene Expression and Role of NiaR as a Transcriptional Repressor ofFrontiers in cellular and infection microbiology · 2017Article
- Functional mining of transporters using synthetic selections.Nature chemical biology · 2016Article
- Characterization of NAD salvage pathways and their role in virulence in Streptococcus pneumoniae.Microbiology (Reading, England) · 2015Article
- Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog.Nature structural & molecular biology · 2014Article
- Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.The Journal of biological chemistry · 2011Article
- Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.Biochimica et biophysica acta · 2010Review
- Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.The Journal of biological chemistry · 2009Article
- Nitrogen recycling and nutritional provisioning by Blattabacterium, the cockroach endosymbiont.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.The Journal of biological chemistry · 2009Article
- Moraxella catarrhalis synthesizes an autotransporter that is an acid phosphatase.Journal of bacteriology · 2008Article
- Identification of mutations that alter the gating of the Escherichia coli mechanosensitive channel protein, MscK.Molecular microbiology · 2007Article
- NAD+ utilization in Pasteurellaceae: simplification of a complex pathway.Journal of bacteriology · 2006Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Salmonella enterica can obtain pyridine from exogenous nicotinamide mononucleotide (NMN) by three routes. In route 1, nicotinamide is removed from NMN in the periplasm and enters the cell as the free base. In route 2, described here, phosphate is removed from NMN in the periplasm by acid phosphatase (AphA), and the produced nicotinamide ribonucleoside (NmR) enters the cell via the PnuC transporter. Internal NmR is then converted back to NMN by the NmR kinase activity of NadR. Route 3 is seen only in pnuC* transporter mutants, which import NMN intact and can therefore grow on lower levels of NMN. Internal NMN produced by either route 2 or route 3 is deamidated to nicotinic acid mononucleotide and converted to NAD by the biosynthetic enzymes NadD and NadE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.