ArticleJournal of bacteriology2005
Mutational analysis of a bifunctional ferrisiderophore receptor and signal-transducing protein from Pseudomonas aeruginosa.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Bacterial TonB-dependent transducers interact with the anti-σ factor in absence of the inducing signal protecting it from proteolysis.PLoS biology · 2024Article
- Bacterial cell sensing and signaling pathway for external polycyclic aromatic hydrocarbons (PAHs).iScience · 2023Article
- Impact of Mt. Olympus Honeys on Virulence Factors Implicated in Pathogenesis Exerted byAntibiotics (Basel, Switzerland) · 2023Article
- Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Study on pyoverdine and biofilm production with detection of LasR gene in MDRSaudi journal of biological sciences · 2023Article
- Loss of a pyoverdine secondary receptor in Pseudomonas aeruginosa results in a fitter strain suitable for population invasion.The ISME journal · 2021Article
- The biosynthesis of pyoverdines.Microbial cell (Graz, Austria) · 2018Review
- Activation of a Cell Surface Signaling Pathway inFrontiers in microbiology · 2017Article
- Role of Iron Uptake Systems in Pseudomonas aeruginosa Virulence and Airway Infection.Infection and immunity · 2016Article
- Pyoverdine and proteases affect the response of Pseudomonas aeruginosa to gallium in human serum.Antimicrobial agents and chemotherapy · 2015Article
- Interactions between an anti-sigma protein and two sigma factors that regulate the pyoverdine signaling pathway in Pseudomonas aeruginosa.BMC microbiology · 2014Article
- Deciphering protein dynamics of the siderophore pyoverdine pathway in Pseudomonas aeruginosa.PloS one · 2013Article
- Role of TonB1 in pyoverdine-mediated signaling in Pseudomonas aeruginosa.Journal of bacteriology · 2009Article
- Role of cell surface signaling in proteolysis of an alternative sigma factor in Pseudomonas aeruginosa.Journal of bacteriology · 2008Article
- Salicylic acid, yersiniabactin, and pyoverdin production by the model phytopathogen Pseudomonas syringae pv. tomato DC3000: synthesis, regulation, and impact on tomato and Arabidopsis host plants.Journal of bacteriology · 2007Article
- Heme and a five-amino-acid hemophore region form the bipartite stimulus triggering the has signaling cascade.Journal of bacteriology · 2006Article
- FpvA-mediated ferric pyoverdine uptake in Pseudomonas aeruginosa: identification of aromatic residues in FpvA implicated in ferric pyoverdine binding and transport.Journal of bacteriology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The FpvA protein of Pseudomonas aeruginosa strain PAO1 mediates uptake of a siderophore, ferripyoverdine. It is also a component of a signal transduction pathway that controls production of an exotoxin, a protease, pyoverdine, and FpvA itself. The purpose of the research described here was to dissect these different functions of FpvA. Signaling involves an N-terminal domain of FpvA, and it was shown that this domain is probably located in the periplasm, as expected. Short peptides were inserted at 36 sites within FpvA by linker insertion mutagenesis. The effects of these mutations on the presence of FpvA in the outer membrane, on FpvA-mediated uptake of ferripyoverdine, and on pyoverdine synthesis and gene expression were determined. Five of the mutations resulted in the absence of FpvA from the outer membrane of the bacteria. All of the remaining mutations eliminated either the transport or signaling function of FpvA and most affected both functions. Three mutations prevented transport of ferripyoverdine but had no effect on the signal transduction pathway showing that transport of ferripyoverdine is not required for the trans-membrane signaling process. Conversely, eight mutations affected pyoverdine-mediated signaling but had no effect on transport of ferripyoverdine. These data show that insertions throughout FpvA resulted in loss of function and that signaling and transport are separate and discrete functions of FpvA.
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