ArticleJournal of bacteriology2005
Phenylacetate catabolism in Rhodococcus sp. strain RHA1: a central pathway for degradation of aromatic compounds.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 105 citations in OpenAlex.
- Conservation, origin, and remodeling of the phenyl acetate degradation pathway.Microbial genomics · 2026Article
- Predicting rhizosphere-competence-related catabolic gene clusters in plant-associated bacteria with rhizoSMASH.Nature communications · 2025Article
- Phenylacetic acid metabolism in land plants: novel pathways and metabolites.Journal of experimental botany · 2025Article
- Surfing in the storm: how Paraburkholderia xenovorans thrives under stress during biodegradation of toxic aromatic compounds and other stressors.FEMS microbiology reviews · 2025Review
- Aerobic Degradation Characteristics of Decabromodiphenyl ether throughMicroorganisms · 2022Article
- Postdiagenetic Changes in Kerogen Properties and Type by Bacterial Oxidation and Dehydrogenation.Molecules (Basel, Switzerland) · 2022Article
- Analysis of the biodegradative and adaptive potential of the novel polychlorinated biphenyl degraderMicrobial genomics · 2020Article
- Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports.BMC nephrology · 2019Article
- New insights into the genome of Rhodococcus ruber strain Chol-4.BMC genomics · 2019Article
- Environmental interactions are regulated by temperature in Burkholderia seminalis TC3.4.2R3.Scientific reports · 2019Article
- Discovery of potential pathways for biological conversion of poplar wood into lipids by co-fermentation ofBiotechnology for biofuels · 2019Article
- Organic micropollutants paracetamol and ibuprofen-toxicity, biodegradation, and genetic background of their utilization by bacteria.Environmental science and pollution research international · 2018Review
- On the Enigma of Glutathione-Dependent Styrene Degradation in Gordonia rubripertincta CWB2.Applied and environmental microbiology · 2018Article
- Genomic insights of aromatic hydrocarbon degrading3 Biotech · 2018Article
- A Review: The Styrene Metabolizing Cascade of Side-Chain Oxygenation as Biotechnological Basis to Gain Various Valuable Compounds.Frontiers in microbiology · 2018Review
- Genome Sequencing and Comparative Transcriptomics Provide a Holistic View of 4-Nitrophenol Degradation and Concurrent Fatty Acid Catabolism byFrontiers in microbiology · 2018Article
- Nutrient starvation leading to triglyceride accumulation activates the Entner Doudoroff pathway in Rhodococcus jostii RHA1.Microbial cell factories · 2017Article
- Characterization of key triacylglycerol biosynthesis processes in rhodococci.Scientific reports · 2016Article
- Isolation and genome sequencing of four Arctic marine Psychrobacter strains exhibiting multicopper oxidase activity.BMC genomics · 2016Article
- Regulation of plasmid-encoded isoprene metabolism in Rhodococcus, a representative of an important link in the global isoprene cycle.Environmental microbiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In gram-negative bacteria, a pathway for aerobic degradation of phenylacetic acid (PAA) that proceeds via phenylacetyl-coenzyme A (CoA) and hydrolytic ring fission plays a central role in the degradation of a range of aromatic compounds. In contrast, the PAA pathway and its role are not well characterized in gram-positive bacteria. A cluster including 13 paa genes encoding enzymes orthologous to those of gram-negative bacteria was identified on the chromosome of Rhodococcus sp. strain RHA1. These genes were transcribed during growth on PAA, with 11 of the genes apparently in an operon yielding a single transcript. Quantitative proteomic analyses revealed that at least 146 proteins were more than twice as abundant in PAA-grown cells of RHA1 than in pyruvate-grown cells. Of these proteins, 29 were identified, including 8 encoded by the paa genes. Knockout mutagenesis indicated that paaN, encoding a putative ring-opening enzyme, was essential for growth on PAA. However, paaF, encoding phenylacetyl-CoA ligase, and paaR, encoding a putative regulator, were not essential. paaN was also essential for growth of RHA1 on phenylacetaldehyde, phenylpyruvate, 4-phenylbutyrate, 2-phenylethanol, 2-phenylethylamine, and l-phenylalanine. In contrast, growth on 3-hydroxyphenylacetate, ethylbenzene, and styrene was unaffected. These results suggest that the range of substrates degraded via the PAA pathway in RHA1 is somewhat limited relative to the range in previously characterized gram-negative bacteria.
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