ArticleThe Journal of biological chemistry2005
MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival.
Article in The Journal of biological chemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Trial
- Decoding the Raf-Mek-Erk-Rsk pathway in prostate cancer: from molecular mechanisms to clinical opportunities.British journal of cancer · 2026Review
- E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.The Journal of clinical investigation · 2020Article
- Mechanism of inhibition of Shiga-toxigenicCell death discovery · 2018Article
- Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells.Neuro-oncology · 2014Article
- Functions and regulation of MUC13 mucin in colon cancer cells.Journal of gastroenterology · 2014Article
- Inferring protein modulation from gene expression data using conditional mutual information.PloS one · 2014Article
- Transcriptional mechanisms underlying hemoglobin synthesis.Cold Spring Harbor perspectives in medicine · 2013Review
- Constitutive phosphorylation of GATA-1 at serine²⁶ attenuates the colony-forming activity of erythrocyte-committed progenitors.PloS one · 2013Article
- GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism.PloS one · 2013Article
- Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies.Nucleic acids research · 2012Review
- DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development.European journal of immunology · 2012Article
- Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis.Cellular signalling · 2011Article
- Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.Neoplasia (New York, N.Y.) · 2011Article
- Cord blood administration induces oligodendrocyte survival through alterations in gene expression.Brain research · 2010Article
- E4BP4 is a cardiac survival factor and essential for embryonic heart development.Molecular and cellular biochemistry · 2010Article
- SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.The Journal of experimental medicine · 2010Article
- Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.The Journal of clinical investigation · 2010Article
- Article
- Up-regulation of Bcl-xl by hepatocyte growth factor in human mesothelioma cells involves ETS transcription factors.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
In the interleukin 3-dependent hematopoietic cell line Ba/F3, inhibition of mitogen-activated protein kinase, a member of the MAPK/c-Jun N-terminal kinase/stress-activated protein kinase kinase family that plays an important role in cell growth and death control, rapidly leads to severe apoptosis. However, most of the antiapoptotic substrates of MAPK remain to be identified. Here we report that, upon interleukin-3 stimulation of Ba/F3 cells, the transcription factor GATA-1 is strongly phosphorylated at residue serine 26 by a MAPK-dependent pathway. Phosphorylation of GATA-1 increases GATA-1-mediated transcription of the E4bp4 survival gene without significantly changing the DNA-binding affinity of GATA-1. Further characterization of GATA-1 phosphorylation site mutants revealed that the antiapoptotic function of GATA-1 is strongly dependent upon its phosphorylation at the Ser-26 position and is probably mediated through its up-regulation of Bcl-X(L) expression. Taken together, our data demonstrate that MAPK-dependent GATA-1 phosphorylation is important for its transactivation of the E4bp4 gene, Bcl-X(L) expression and cell survival. Therefore, GATA-1 may represent a novel MAPK substrate that plays an essential role in a cytokine-mediated antiapoptotic response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.