ArticleGenetics2005
Haplotype diversity in 11 candidate genes across four populations.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Evolutionary relationships and genetic diversity in theBiochemistry and biophysics reports · 2025Article
- From genomic discovery to application in age-related hearing loss: a global bibliometric and cross-ethnic analysis.Frontiers in aging neuroscience · 2025Article
- [Analysis of single-nucleotide polymorphism of Sonic hedgehog signaling pathway in non-syndromic cleft lip and/or palate in the Chinese population].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Article
- Association of polymorphisms in genes of factors involved in regulation of splicing of cystic fibrosis transmembrane conductance regulator mRNA with acute respiratory distress syndrome in children with pneumonia.Critical care (London, England) · 2016Article
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- Genome-wide SNP and population divergence of finless porpoises.Genome biology and evolution · 2013Article
- Association of cystic fibrosis transmembrane conductance regulator gene variants with acute lung injury in African American children with pneumonia*.Critical care medicine · 2012Article
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- CAS proteins in normal and pathological cell growth control.Cellular and molecular life sciences : CMLS · 2010Review
- Association mapping and marker-assisted selection of the lettuce dieback resistance gene Tvr1.BMC plant biology · 2009Article
- Perl module and PISE wrappers for the integrated analysis of sequence data and SNP features.BMC research notes · 2009Article
- Scanning the genome for gene single nucleotide polymorphisms involved in adaptive population differentiation in white spruce.Molecular ecology · 2008Article
- Using population mixtures to optimize the utility of genomic databases: linkage disequilibrium and association study design in India.Annals of human genetics · 2008Article
- Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4.Genomics · 2008Article
- Comparison of ENCODE region SNPs between Cebu Filipino and Asian HapMap samples.Journal of human genetics · 2007Article
- Efficient selection of tagging single-nucleotide polymorphisms in multiple populations.Human genetics · 2006Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Analysis of haplotypes based on multiple single-nucleotide polymorphisms (SNP) is becoming common for both candidate gene and fine-mapping studies. Before embarking on studies of haplotypes from genetically distinct populations, however, it is important to consider variation both in linkage disequilibrium (LD) and in haplotype frequencies within and across populations, as both vary. Such diversity will influence the choice of "tagging" SNPs for candidate gene or whole-genome association studies because some markers will not be polymorphic in all samples and some haplotypes will be poorly represented or completely absent. Here we analyze 11 genes, originally chosen as candidate genes for oral clefts, where multiple markers were genotyped on individuals from four populations. Estimated haplotype frequencies, measures of pairwise LD, and genetic diversity were computed for 135 European-Americans, 57 Chinese-Singaporeans, 45 Malay-Singaporeans, and 46 Indian-Singaporeans. Patterns of pairwise LD were compared across these four populations and haplotype frequencies were used to assess genetic variation. Although these populations are fairly similar in allele frequencies and overall patterns of LD, both haplotype frequencies and genetic diversity varied significantly across populations. Such haplotype diversity has implications for designing studies of association involving samples from genetically distinct populations.
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