ArticleGenetics2005
X-linked genes evolve higher codon bias in Drosophila and Caenorhabditis.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
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- Hemizygosity Enhances Purifying Selection: Lack of Fast-Z Evolution in Two Satyrine Butterflies.Genome biology and evolution · 2016Article
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- Effective population size does not predict codon usage bias in mammals.Ecology and evolution · 2014Article
- Positive and purifying selection on the Drosophila Y chromosome.Molecular biology and evolution · 2014Article
- Background selection as baseline for nucleotide variation across the Drosophila genome.PLoS genetics · 2014Article
- Faster-X adaptive protein evolution in house mice.Genetics · 2014Article
- Genome of Drosophila suzukii, the spotted wing drosophila.G3 (Bethesda, Md.) · 2013Article
- Pleiotropic constraints, expression level, and the evolution of miRNA sequences.Journal of molecular evolution · 2013Article
- Strong purifying selection at synonymous sites in D. melanogaster.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Comparing patterns of molecular evolution between autosomes and sex chromosomes (such as X and W chromosomes) can provide insight into the forces underlying genome evolution. Here we investigate patterns of codon bias evolution on the X chromosome and autosomes in Drosophila and Caenorhabditis. We demonstrate that X-linked genes have significantly higher codon bias compared to autosomal genes in both Drosophila and Caenorhabditis. Furthermore, genes that become X-linked evolve higher codon bias gradually, over tens of millions of years. We provide several lines of evidence that this elevation in codon bias is due exclusively to their chromosomal location and not to any other property of X-linked genes. We present two possible explanations for these observations. One possibility is that natural selection is more efficient on the X chromosome due to effective haploidy of the X chromosomes in males and persistently low effective numbers of reproducing males compared to that of females. Alternatively, X-linked genes might experience stronger natural selection for higher codon bias as a result of maladaptive reduction of their dosage engendered by the loss of the Y-linked homologs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.