ArticleJournal of neurology, neurosurgery, and psychiatry2005
Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer's disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 252 citations in OpenAlex.
- Meta-analytic Review of Memory Impairment in Behavioral Variant Frontotemporal Dementia.Journal of the International Neuropsychological Society : JINS · 2018Pooled it
- Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review.Journal of neurology, neurosurgery, and psychiatry · 2007Pooled it
- Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights.Journal of clinical medicine · 2024Review
- Mental capacity assessment in the multi-professional real world: a qualitative study of six areas of uncertainty.Wellcome open research · 2024Article
- Frontotemporal Dementia, Where Do We Stand? A Narrative Review.International journal of molecular sciences · 2023Review
- Article
- The Impact of Hearing Loss and Hearing Aid Usage on the Visuospatial Abilities of Older Adults in a Cohort of Combined Hearing and Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample.Frontiers in neurology · 2021Article
- Cognitive and behavioural inhibition deficits in neurodegenerative dementias.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Review
- Does Episodic Memory Training Improve Episodic Memory of Older Adults with Alzheimer's Disease?Brain & NeuroRehabilitation · 2020Article
- Marrying Past and Present Neuropsychology: Is the Future of the Process-Based Approach Technology-Based?Frontiers in psychology · 2020Review
- Analyzing theory of mind impairment in patients with behavioral variant frontotemporal dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Neuropsychological differentiation of progressive aphasic disorders.Journal of neuropsychology · 2019Article
- The role of lysosomes and autophagosomes in frontotemporal lobar degeneration.Neuropathology and applied neurobiology · 2019Article
- Psychological and Cognitive Markers of Behavioral Variant Frontotemporal Dementia-A Clinical Neuropsychologist's View on Diagnostic Criteria and Beyond.Frontiers in neurology · 2019Review
- Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease.Acta neuropathologica · 2018Article
- Parietal Involvement in Constructional Apraxia as Measured Using the Pentagon Copying Task.Dementia and geriatric cognitive disorders · 2018Article
- Theoretical Modeling of Cognitive Dysfunction in Schizophrenia by Means of Errors and Corresponding Brain Networks.Frontiers in psychology · 2018Review
- Examining the language and behavioural profile in FTD and ALS-FTD.Journal of neurology, neurosurgery, and psychiatry · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrontotemporal dementia (FTD) and Alzheimer's disease are clinically distinct disorders, yet neuropsychological studies have had variable success in distinguishing them. A possible reason is that studies typically rely on overall accuracy scores, which may obscure differences in reasons for failure.
objectivesTo explore the hypothesis that analysis of qualitative performance characteristics and error types, in addition to overall numerical scores, would enhance the neuropsychological distinction between FTD and Alzheimer's disease.
methods38 patients with FTD and 73 with Alzheimer's disease underwent assessment of language, visuospatial abilities, memory, and executive function, using a neuropsychological screening instrument and standard neuropsychological tests. In each of these cognitive domains, performance characteristics and error types were documented, in addition to numerical scores on tests.
resultsWhereas comparison of neuropsychological test scores revealed some group differences, these did not occur consistently across tests within cognitive domains. However, analysis of performance characteristics and error types revealed qualitative differences between the two groups. In particular, FTD patients displayed features associated with frontal lobe dysfunction, such as concrete thought, perseveration, confabulation, and poor organisation, which disrupted performance across the range of neuropsychological tests.
conclusionsNumerical scores on neuropsychological tests alone are of limited value in differentiating FTD and Alzheimer's disease, but performance characteristics and error types enhance the distinction between the two disorders. FTD is associated with a profound behavioural syndrome that affects performance on cognitive assessment, obscuring group differences. Qualitative information should be included in neuropsychological research and clinical assessments.
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