ArticleThe British journal of ophthalmology2005
TLRs and NODs mRNA expression pattern in healthy mouse eye.
Article in The British journal of ophthalmology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome.Journal of neuroinflammation · 2024Review
- Article
- Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy.International journal of molecular sciences · 2020Review
- Toll-like Receptor 1/2 Agonist Pam3CSK4 Suppresses Lipopolysaccharide-driven IgG1 Production while Enhancing IgG2a Production by B Cells.Immune network · 2018Article
- Article
- Efficacy of the nucleotide-binding oligomerzation domain 1 inhibitor Nodinhibit-1 on corneal alkali burns in rats.International journal of ophthalmology · 2015Article
- Innate and adaptive immune response to pneumonia virus of mice in a resistant and a susceptible mouse strain.Viruses · 2013Article
- Peptidoglycan and muramyl dipeptide from Staphylococcus aureus induce the expression of VEGF-A in human limbal fibroblasts with the participation of TLR2-NFκB and NOD2-EGFR.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013Article
- Toll-like receptor 2 ligand pretreatment attenuates retinal microglial inflammatory response but enhances phagocytic activity toward Staphylococcus aureus.Infection and immunity · 2012Article
- Nucleotide oligomerization domain 2 contributes to the innate immune response in THCE cells stimulated by Aspergillus fumigatus conidia.International journal of ophthalmology · 2012Article
- Investigation of the differential potentials of TLR agonists to elicit uveitis in mice.Journal of leukocyte biology · 2011Article
- NLRs in immune privileged sites.Current opinion in pharmacology · 2011Review
- Peptidoglycan from Staphylococcus aureus induces the overexpression of TRLs 1-8 mRNA in corneal fibroblasts, but its lipoteichoic acid and muramyl dipeptide only induced the overexpression of TLR5 or TRL9.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- TLR2 mediates the innate response of retinal Muller glia to Staphylococcus aureus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Toll-like receptors involved in the pathogenesis of experimental Candida albicans keratitis.Investigative ophthalmology & visual science · 2010Article
- NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice.Investigative ophthalmology & visual science · 2009Article
- Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma.Investigative ophthalmology & visual science · 2009Article
- Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors.Journal of molecular medicine (Berlin, Germany) · 2009Review
- The involvement of the Toll-like receptor family in ovulation.Journal of assisted reproduction and genetics · 2008Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo look for TLR and NOD mRNA expression in the healthy eye and in other immune privileged and non-immune privileged mouse organs.
methodsSemiquantitative RT-PCR was performed to look for TLR1-9 and NOD1 and NOD2 mRNA expressions in the whole eye, in the anterior (AP) and posterior (PP) portions of the eye, in corneal fibroblasts (CF) and in ovary, brain, testis, heart, lung, and spleen.
resultsAll the TLR mRNAs were expressed in the whole eye of Balb/c mice. NIH and C57BL/6 did not express TLR9 and TLR8, respectively. NIH expressed higher levels of TLR1, 2, 3, and 6 than the other strains. C57BL/6 expressed the lowest levels of all TLRs. TLR9, 5, and 4 were the less expressed in all strains. All TLRs were expressed in Balb/c PP and TLR1 was not expressed in AP. In NIH and Balb/c CF the majority of TLRs were overexpressed with LPS. In testis, expression of most TLRs was absent. Non-immune privileged organs expressed most of the TLRs. All the organs expressed NOD1 and NOD2. In PP NOD2 was not expressed.
conclusionTLRs and NODs are expressed in the eye, and could have an important role in the innate immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.