ArticleGenes & development2005
Guanosine triphosphate acts as a cofactor to promote assembly of initial P-element transposase-DNA synaptic complexes.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Article
- Article
- Activity of zebrafish THAP9 transposase and zebrafish P element-like transposons.bioRxiv : the preprint server for biology · 2024Article
- Article
- Mechanism and regulation of P element transposition.Open biology · 2020Review
- Transposable elements inMobile DNA · 2020Review
- Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts.Nature structural & molecular biology · 2019Article
- Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- P Transposable Elements in Drosophila and other Eukaryotic Organisms.Microbiology spectrum · 2015Review
- The emerging diversity of transpososome architectures.Quarterly reviews of biophysics · 2012Review
- A green fluorescent protein solubility screen in E. coli reveals domain boundaries of the GTP-binding domain in the P element transposase.Protein science : a publication of the Protein Society · 2010Article
- Molecular mechanism underlying RAG1/RAG2 synaptic complex formation.The Journal of biological chemistry · 2009Article
- Testing the palindromic target site model for DNA transposon insertion using the Drosophila melanogaster P-element.Nucleic acids research · 2008Article
- Dissecting the roles of MuB in Mu transposition: ATP regulation of DNA binding is not essential for target delivery.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Coincidence of P-insertion sites and breakpoints of deletions induced by activating P elements in Drosophila.Genetics · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
P transposable elements in Drosophila are members of a larger class of mobile elements that move using a cut-and-paste mechanism. P-element transposase uses guanosine triphosphate (GTP) as a cofactor for transposition. Here, we use atomic force microscopy (AFM) to visualize protein-DNA complexes formed during the initial stages of P-element transposition. These studies reveal that GTP acts to promote assembly of the first detectable noncovalent precleavage synaptic complex. This initial complex then randomly and independently cleaves each P-element end. These data show that GTP acts to promote protein-DNA assembly, and may explain why P-element excision often leads to unidirectional deletions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.