ArticleMolecular and cellular biology2005
Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- A bibliometric and visual analysis of PRMTs research publications for cancer (2006-2024).Medicine · 2026Article
- Citrullination in health and disease: From physiological function to gene regulation.Genes & diseases · 2025Review
- Oligomerization of protein arginine methyltransferase 1 and its effect on methyltransferase activity and substrate specificity.Protein science : a publication of the Protein Society · 2024Article
- PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma.Nature communications · 2023Article
- The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.Nature communications · 2022Article
- Global analysis of protein arginine methylation.Cell reports methods · 2021Article
- Histone citrullination: a new target for tumors.Molecular cancer · 2021Review
- Salmonella enterica serovar Typhi exposure elicits ex vivo cell-type-specific epigenetic changes in human gut cells.Scientific reports · 2020Article
- Arginine methyltransferase inhibitor-1 inhibits sarcoma viabilityOncology letters · 2018Article
- Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
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- PRMT4 is a novel coactivator of c-Myb-dependent transcription in haematopoietic cell lines.PLoS genetics · 2013Article
- Article
- Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation.Advances in immunology · 2013Review
- Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication.Nature communications · 2013Article
- Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation.PloS one · 2013Article
- Cellular functions of tissue transglutaminase.International review of cell and molecular biology · 2012Review
- STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.Immunity · 2010Article
- Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.The Journal of biological chemistry · 2010Article
- Histone arginine methylations: their roles in chromatin dynamics and transcriptional regulation.Bioscience reports · 2009Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Cellular differentiation is governed by changes in gene expression, but at the same time, a cell's identity needs to be maintained through multiple cell divisions during maturation. In myeloid cell lines, retinoids induce gene expression and a well-characterized two-step lineage-specific differentiation. To identify mechanisms that contribute to cellular transcriptional memory, we analyzed the epigenetic changes taking place on regulatory regions of tissue transglutaminase, a gene whose expression is tightly linked to retinoid-induced differentiation. Here we report that the induction of an intermediary or "primed" state of myeloid differentiation is associated with increased H4 arginine 3 and decreased H3 lysine 4 methylation. These modifications occur before transcription and appear to prime the chromatin for subsequent hormone-regulated transcription. Moreover, inhibition of methyltransferase activity, pre-acetylation, or activation of the enzyme PAD4 attenuated retinoid-regulated gene expression, while overexpression of PRMT1, a methyltransferase, enhanced retinoid responsiveness. Taken together, our results suggest that H4 arginine 3 methylation is a bona fide positive epigenetic marker and regulator of transcriptional responsiveness as well as a signal integration mechanism during cell differentiation and, as such, may provide epigenetic memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.