ArticleMolecular and cellular biology2005
DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Regulation of Body Size and Growth Control.Genetics · 2020Review
- Selective repression of the Drosophila cyclin B promoter by retinoblastoma and E2F proteins.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Article
- DREF Genetically Counteracts Mi-2 and Caf1 to Regulate Adult Stem Cell Maintenance.PLoS genetics · 2019Article
- Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers.PloS one · 2018Article
- Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors.Trends in genetics : TIG · 2016Review
- Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila.PloS one · 2015Article
- Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1.Biochimica et biophysica acta · 2013Article
- Dynamic changes in the genomic localization of DNA replication-related element binding factor during the cell cycle.Cell cycle (Georgetown, Tex.) · 2013Article
- RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.Molecular and cellular biology · 2012Article
- Combinatorial control of temporal gene expression in the Drosophila wing by enhancers and core promoters.BMC genomics · 2012Article
- XNP/dATRX interacts with DREF in the chromatin to regulate gene expression.Nucleic acids research · 2012Article
- The warts gene as a novel target of the Drosophila DRE/DREF transcription pathway.American journal of cancer research · 2012Article
- DREF is involved in the steroidogenesis via regulation of shadow gene.American journal of cancer research · 2012Article
- Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing.Nucleic acids research · 2011Article
- Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex.Molecular genetics and genomics : MGG · 2011Article
- Article
- C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.Developmental biology · 2010Article
- Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF.Nucleic acids research · 2009Article
- Functional analysis of Drosophila polytene chromosomes decompacted unit: the interband.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Based on overexpression studies and target gene analyses, the transcription factor DNA replication-related element factor (DREF) has been proposed to regulate growth and replication in Drosophila melanogaster. Here we present loss-of-function experiments to analyze the contribution of DREF to these processes. RNA interference-mediated extinction of DREF function in vivo demonstrates a requirement for the protein for normal progression through the cell cycle and consequently for growth of imaginal discs and the derived adult organs. We show that DREF regulates the expression of genes that are required for the transition of imaginal disc cells through S phase. In conditions of suppressed apoptosis, DREF activation can cause overgrowth of developing organs. These data establish DREF as a global regulator of transcriptional programs that mediate cell proliferation and organ growth during animal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.