ArticleMolecular and cellular biology2005
Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78 citing papers in PubMed.
- Large-scale comparative analysis of the nuclear factor-Y transcription factors across 320 horticultural and other plants.Horticulture research · 2026Article
- Molecular Mechanisms of NF-Y Transcription Factors in Horticultural Plant Development and Stress Responses: Recent Advances.International journal of molecular sciences · 2026Review
- Transcription factor NFYA3_0 promotes MTA-mediated mPlant communications · 2026Article
- Nuclear factor-Y transcription factors in crops: Biological roles, regulation, and breeding applications.Plant communications · 2025Review
- The Nuclear Transcription FactorInternational journal of molecular sciences · 2025Article
- Genome Editing of thePlants (Basel, Switzerland) · 2025Article
- Article
- Molecular condensation of the CO/NF-YB/NF-YC/FT complex gates floral transition in Arabidopsis.The EMBO journal · 2025Article
- Genomic identification of theMolecular breeding : new strategies in plant improvement · 2025Article
- Plant Nuclear Factor Y (NF-Y) Transcription Factors: Evolving Insights into Biological Functions and Gene Expansion.International journal of molecular sciences · 2024Review
- Article
- Nuclear factor Y-A3b binds to theHorticulture research · 2024Article
- Article
- Genome-Wide Identification and Drought Stress Response Pattern of the NF-Y Gene Family inInternational journal of molecular sciences · 2024Article
- Regulatory microRNAs and phasiRNAs of paclitaxel biosynthesis inFrontiers in plant science · 2024Article
- Review
- Characterization of Chromatin Accessibility in Fetal Bovine Chondrocytes.Animals : an open access journal from MDPI · 2023Article
- Article
- Evolutionary insights and expression dynamics of the CaNFYB transcription factor gene family in pepper (Frontiers in genetics · 2023Article
- Transcription factors ZmNF-YA1 and ZmNF-YB16 regulate plant growth and drought tolerance in maize.Plant physiology · 2022Article
18 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
The transcriptional activator NF-Y is a heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC, which specifically binds the CCAAT consensus present in about 30% of eukaryotic promoters. All three subunits contain evolutionarily conserved core regions, which comprise a histone fold motif (HFM) in the case of NF-YB and NF-YC. Our results of in vitro binding studies and nuclear import assays reveal two different transport mechanisms for NF-Y subunits. While NF-YA is imported by an importin beta-mediated pathway, the NF-YB/NF-YC heterodimer is translocated into the nucleus in an importin 13-dependent manner. We define a nonclassical nuclear localization signal (ncNLS) in NF-YA, and mutational analysis indicates that positively charged amino acid residues in the ncNLS are required for nuclear targeting of NF-YA. Importin beta binding is restricted to the monomeric, uncomplexed NF-YA subunit. In contrast, the nuclear import of NF-YB and NF-YC requires dimer formation. Only the NF-YB/NF-YC dimer, but not the monomeric components, are recognized by importin 13 and are imported into the nucleus. Importin 13 competes with NF-YA for binding to the NF-YB/NF-YC dimer. Our data suggest that a distinct binding platform derived from the HFM of both subunits, NF-YB/NF-YC, mediates those interactions.
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