ArticleWorld journal of gastroenterology2005
A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of Barrett's Esophagus in Asian Countries: A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Pooled it
- Treatment of non-erosive reflux disease with a proton pump inhibitor in Chinese patients: a randomized controlled trial.Journal of gastroenterology · 2011Trial
- Upper gastrointestinal endoscopy in patients with gastroesophageal reflux disease symptoms: Correlating endoscopic findings with symptoms and pH-impedance results.World journal of gastrointestinal endoscopy · 2026Article
- Endoscopic Evaluation of the Gastroesophageal Junction and Diagnosis of Barrett's Esophagus.Digestion · 2026Review
- Article
- Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis.Journal of neurogastroenterology and motility · 2022Review
- Clinical features and therapeutic responses to proton pump inhibitor in patients with severe reflux esophagitis: A multicenter prospective observational study.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Anxiety and depression in patients with gastroesophageal reflux disorder.Electronic physician · 2017Article
- Central Obesity as a Risk Factor for Non-Erosive Reflux Disease.Yonsei medical journal · 2017Article
- Minimal endoscopic changes in non-erosive reflux disease.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2015Article
- Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern.World journal of gastrointestinal pathophysiology · 2011Article
- Short-segment Barrett's esophagus and cardia intestinal metaplasia: A comparative analysis.World journal of gastroenterology · 2010Article
- Role of digital chromoendoscopy in detecting minimal change esophageal reflux disease.World journal of gastrointestinal endoscopy · 2010Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the clinical spectrum of gastroesophageal reflux disease (GERD) and compare erosive (ERD) with non-erosive (NERD) in terms of clinical, demographic and psychiatric profiles.
methodsPatients with reflux symptoms were enrolled and stratified to NERD and ERD after endoscopy (LA classification). Patients with ERD presenting with dyspepsia were included. Patients on proton pump inhibitors (PPI) or H2 receptor antagonists before endoscopy were excluded. Demographic data, Helicobacter pylori (H pylori) status and presence of minor psychiatric morbidity (based on General Health Questionnaire-28) were analyzed.
resultsAmong 690 patients screened, 533 were eligible for analysis (male to female ratio: 3:2; Chinese: 75.4%; Malay: 9.8%; Indian: 14.8%). Clinical spectrum of GERD: N: 40.5%; A: 46%; B: 9.2%; C: 2.1%; D: 0.6%; Barrett's esophagus: 1.7%. Compared to patients with NERD, patients with ERD were significantly older (45 vs 39.4 years), more likely to be male (64.4% vs 53.7%), tended to smoke (19.6% vs 9.7%), less likely to have minor psychiatric morbidity (26.4 vs 46.7%) and were more likely to respond to PPI (79.7 vs 66.8%). There was also a trend towards a higher BMI (24.5 vs 23.5). Race, alcohol consumption and H pylori status were not significant. On multivariate analysis, age and presence of minor psychiatric morbidity remained with significant differences.
conclusionThe majority of patients who have typical symptoms of GERD have NERD or mild erosive reflux disease. Compared to patients with erosive reflux disease, patients with NERD were younger and had a higher prevalence of minor psychiatric morbidity.
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