ArticleHepatology (Baltimore, Md.)2005
Activation and function of hepatocyte NF-kappaB in postischemic liver injury.
Article in Hepatology (Baltimore, Md.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- A20 rescues hepatocytes from apoptosis through the NF-κB signaling pathway in rats with acute liver failure.Bioscience reports · 2019Article
- Hem-o-lok Clips Migration: An Easily Neglected Complication after Laparoscopic Biliary Surgery.Case reports in surgery · 2017Article
- Innate Immune Regulations and Liver Ischemia-Reperfusion Injury.Transplantation · 2016Review
- Tubular Epithelial NF-κB Activity Regulates Ischemic AKI.Journal of the American Society of Nephrology : JASN · 2016Article
- Use of a hanging-weight system for liver ischemia in mice.Journal of visualized experiments : JoVE · 2012Article
- IKK biology.Immunological reviews · 2012Review
- Bioluminescence imaging visualizes activation of nuclear factor-kappaB in mouse cardiac transplantation.Transplantation · 2008Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitor of NF-kappaB (I-kappaB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-kappaB essential modulator (NEMO), and is involved in the activation of NF-kappaB by various stimuli. IKK2 or NEMO constitutive knockout mice die during embryogenesis as a result of massive hepatic apoptosis. Therefore, we examined the role of IKK2 in TNF-induced apoptosis and ischemia/reperfusion (I/R) injury in the liver by using conditional knockout mice. Hepatocyte-specific ablation of IKK2 did not lead to impaired activation of NF-kappaB or increased apoptosis after TNF-alpha stimulation whereas conditional NEMO knockout resulted in complete block of NF-kappaB activation and massive hepatocyte apoptosis. In a model of partial hepatic I/R injury, mice lacking IKK2 in hepatocytes displayed significantly reduced liver necrosis and inflammation than wild-type mice. AS602868, a novel chemical inhibitor of IKK2, protected mice from liver injury due to I/R without sensitizing them toward TNF-induced apoptosis and could therefore emerge as a new pharmacological therapy for liver resection, hemorrhagic shock, or transplantation surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.