ReviewMemorias do Instituto Oswaldo Cruz2005
Mechanisms of eosinophil cytokine release.
Review in Memorias do Instituto Oswaldo Cruz, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- Clinical characteristics of peripheral blood eosinophilia in nontuberculous mycobacterial disease: a multicenter comparative retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- Ally, adversary, or arbitrator? The context-dependent role of eosinophils in vaccination for respiratory viruses and subsequent breakthrough infections.Journal of leukocyte biology · 2024Review
- Exosomes: A Key Piece in Asthmatic Inflammation.International journal of molecular sciences · 2021Review
- Type 2/Th2-driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model.Allergy · 2019Article
- Eosinophil Polymorphonuclear Leukocytes in TB: What We Know so Far.Frontiers in immunology · 2019Review
- Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD.Gastroenterology research and practice · 2018Article
- The Regulatory Function of Eosinophils.Microbiology spectrum · 2016Review
- Multifaceted roles of cysteinyl leukotrienes in eliciting eosinophil granule protein secretion.BioMed research international · 2015Review
- Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS.Parasitology research · 2011Article
- Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy?Clinical and experimental immunology · 2010Article
- Vesicle-mediated secretion of human eosinophil granule-derived major basic protein.Laboratory investigation; a journal of technical methods and pathology · 2009Article
- Leukocyte lipid bodies - Biogenesis and functions in inflammation.Biochimica et biophysica acta · 2009Review
- Eosinophil granules function extracellularly as receptor-mediated secretory organelles.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.