ArticleThe EMBO journal2005
Negative feedback regulation among SR splicing factors encoded by Rbp1 and Rbp1-like in Drosophila.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- At-RS31 orchestrates hierarchical cross-regulation of splicing factors and integrates alternative splicing with TOR-ABA pathways.The New phytologist · 2025Article
- Alternative splicing perspective to prey preference of environmentally friendly biological agent Cryptolaemus montrouzieri.BMC genomics · 2024Article
- The identification of protein and RNA interactors of the splicing factor Caper in the adultFrontiers in molecular neuroscience · 2023Article
- Noise suppression in stochastic genetic circuits using PID controllers.PLoS computational biology · 2021Article
- Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.eLife · 2020Article
- Gene expression noise is affected differentially by feedback in burst frequency and burst size.Journal of mathematical biology · 2017Article
- Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila.Genome research · 2015Article
- Regulation of alternative splicing in Drosophila by 56 RNA binding proteins.Genome research · 2015Article
- SR proteins control a complex network of RNA-processing events.RNA (New York, N.Y.) · 2015Article
- Half pint/Puf68 is required for negative regulation of splicing by the SR splicing factor Transformer2.RNA biology · 2013Article
- Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity.Heredity · 2012Article
- Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position.Nucleic acids research · 2012Article
- Regulation of alternative splicing by the core spliceosomal machinery.Genes & development · 2011Article
- Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.BMC genomics · 2010Article
- Autoregulation of Fox protein expression to produce dominant negative splicing factors.RNA (New York, N.Y.) · 2010Article
- Plant SMU-1 and SMU-2 homologues regulate pre-mRNA splicing and multiple aspects of development.Plant physiology · 2009Article
- Enzyme isoforms may increase phenotypic robustness.Evolution; international journal of organic evolution · 2008Article
- The multiple lives of NMD factors: balancing roles in gene and genome regulation.Nature reviews. Genetics · 2008Review
- DX16 is a novel SR protein phosphorylated by DOA.Molecular and cellular biochemistry · 2008Article
- Identification of RNA binding sequences of Drosophila SR protein DX16.Molecular and cellular biochemistry · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
SR proteins constitute a widely conserved family of splicing regulators. Negative autoregulation of SR proteins has been proposed to exert homeostatic control on the splicing environment, but few examples have been studied and the role of isoforms that lack the RS domain is unclear. We show that genes Rbp1 and Rbp1-like, which encode Drosophila homologs of mammalian SRp20, negatively autoregulate and crossregulate at the level of alternative 3' splice site selection. This adjusts the relative expression of isoforms with either an RS domain or unrelated C-terminal domains (ALT) that are rich in serine and threonine. The effects of RBP1-ALT on splicing of doublesex and Rbp1-like are opposite to those of RBP1-RS and RBP1L-RS. RBP1-ALT and -RS exert opposing negative feedback on the ALT/RS ratio. However, RBP1-ALT inhibits the expression of RBP1-RS while stimulating that of RBP1L-RS. This asymmetry may contribute to changes in the RBP1-RS/RBP1L-RS ratio that are observed during development. These results provide the first example of a feedback-regulated SR protein network with evidence of an active homeostatic role for alternative isoforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.