ArticleThe Journal of physiology2005
The involvement of Cav3.2/alpha1H T-type calcium channels in excitability of mouse embryonic primary vestibular neurones.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Accumulation of KThe Journal of physiology · 2017Article
- Sodium channel diversity in the vestibular ganglion: NaV1.5, NaV1.8, and tetrodotoxin-sensitive currents.Journal of neurophysiology · 2016Article
- Ca(V)3.2 channels and the induction of negative feedback in cerebral arteries.Circulation research · 2014Article
- T-type channels buddy up.Pflugers Archiv : European journal of physiology · 2014Review
- Activation of μ-opioid receptors inhibits calcium-currents in the vestibular afferent neurons of the rat through a cAMP dependent mechanism.Frontiers in cellular neuroscience · 2014Article
- Cooperative activation of the T-type CaV3.2 channel: interaction between Domains II and III.The Journal of biological chemistry · 2013Article
- Hyperpolarization-activated current (I(h)) in vestibular calyx terminals: characterization and role in shaping postsynaptic events.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Postnatal expression of an apamin-sensitive k(ca) current in vestibular calyx terminals.The Journal of membrane biology · 2011Article
- K+ currents in isolated vestibular afferent calyx terminals.Journal of the Association for Research in Otolaryngology : JARO · 2010Article
- Ca(2+) signaling by T-type Ca(2+) channels in neurons.Pflugers Archiv : European journal of physiology · 2009Review
- Ion channels in mammalian vestibular afferents may set regularity of firing.The Journal of experimental biology · 2008Review
- Transgenic mouse lines subdivide medial vestibular nucleus neurons into discrete, neurochemically distinct populations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Heterogeneous potassium conductances contribute to the diverse firing properties of postnatal mouse vestibular ganglion neurons.Journal of neurophysiology · 2006Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca2+ influx through voltage-gated calcium channels probably influences neuronal ontogenesis. Many developing neurones transiently express T-type/Cav3 calcium channels that contribute to their electrical activity and potentially to their morphological differentiation. Here we have characterized the electrophysiological properties and the functional role of a large T-type calcium current that is present in mouse developing primary vestibular neurones at embryonic day E17. This T-type current showed fast activation and inactivation, as well as slow deactivation kinetics. The overlap of activation and inactivation parameters produced a window current between -65 and -45 mV. Recovery from short-term inactivation was slow suggesting the presence of the Cav3.2 subunit. This T-type current was blocked by micromolar concentrations of Ni2+ and was inhibited by fast perfusion velocities in a similar fashion to recombinant Cav3.2 T-type channels expressed in HEK-293 cells. More importantly, current clamp experiments have revealed that the T-current could elicit afterdepolarization potentials during the repolarization phase of action potentials, and occasionally generate calcium spikes. Taken together, we demonstrate that the Cav3.2 subunit is likely to be the main T-type calcium channel subunit expressed in embryonic vestibular neurones and should play a key role in the excitability of these neurones during the ontogenesis of vestibular afferentation.
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