ReviewJournal of neural transmission (Vienna, Austria : 1996)2005
Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Head injury and amyotrophic lateral sclerosis.American journal of epidemiology · 2007Pooled it
- Recent insights from non-mammalian models of brain injuries: an emerging literature.Frontiers in neurology · 2024Review
- The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer's Disease.Frontiers in immunology · 2018Review
- Review
- EFAD transgenic mice as a humanJournal of lipid research · 2017Review
- Not just amyloid: physiological functions of the amyloid precursor protein family.Nature reviews. Neuroscience · 2017Review
- Inhibition of tissue transglutaminase promotes Aβ-induced apoptosis in SH-SY5Y cells.Acta pharmacologica Sinica · 2016Article
- ALS and FTD: an epigenetic perspective.Acta neuropathologica · 2016Review
- Tissue Transglutaminase and Its Product Isopeptide Are Increased in Alzheimer's Disease and APPswe/PS1dE9 Double Transgenic Mice Brains.Molecular neurobiology · 2016Article
- Physical Trauma and Amyotrophic Lateral Sclerosis: A Population-Based Study Using Danish National Registries.American journal of epidemiology · 2016Article
- Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus.Frontiers in molecular neuroscience · 2016Article
- Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Article
- Mechanical stretch exacerbates the cell death in SH-SY5Y cells exposed to paraquat: mitochondrial dysfunction and oxidative stress.Neurotoxicology · 2014Article
- Etiology and pathogenesis of late-onset Alzheimer's disease.Current allergy and asthma reports · 2014Review
- Integration of proteomics, bioinformatics, and systems biology in traumatic brain injury biomarker discovery.Frontiers in neurology · 2013Article
- Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy.Journal of Alzheimer's disease : JAD · 2013Article
- The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model.PloS one · 2013Article
- Brain injury, neuroinflammation and Alzheimer's disease.Frontiers in aging neuroscience · 2013Article
- Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2012Review
- Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic Brain Injury is the leading cause of death and disability among young individuals in our society. Moreover, according to some epidemiological studies, head trauma is one of the most potent environmental risk factors for subsequent development of Alzheimer's disease. Interestingly, pathological features that are present also in Alzheimer's disease (in particular deposition of beta-amyloid protein) were observed in traumatised brains already a few hours after the initial insult. The primary objective of this review is to present methodology and results of numerous recent human and animal studies dealing with this issue. Special emphasis was placed on head trauma experiments in transgenic mouse models of Alzheimer's disease. We further evaluate the connection between traumatic brain insults and subsequent development of dementia and try to differentiate between primary and secondary pathological mechanisms.
Indexed as
Identifiers
15959838What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.