ArticleHuman genetics2005
Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides.
Article in Human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 79 citations in OpenAlex.
- Effects ofFrontiers in cardiovascular medicine · 2022Article
- A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context.Nature communications · 2019Article
- The Regulation of Cbf1 by PAS Kinase Is a Pivotal Control Point for LipogenesisG3 (Bethesda, Md.) · 2019Article
- Article
- Systematic target function annotation of human transcription factors.BMC biology · 2018Article
- The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking.International journal of molecular sciences · 2015Article
- Significant association between upstream transcription factor 1 rs2516839 polymorphism and hepatocellular carcinoma risk: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.Scientific reports · 2014Article
- Thioredoxin Interacting Protein (TXNIP) and Pathogenesis of Diabetic Retinopathy.Journal of clinical & experimental ophthalmology · 2013Article
- Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.The Journal of biological chemistry · 2013Article
- Upstream transcription factor 1 (USF1) polymorphisms associate with Alzheimer's disease-related neuropathological lesions: Tampere Autopsy Study.Brain pathology (Zurich, Switzerland) · 2012Article
- Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.Hypertension (Dallas, Tex. : 1979) · 2012Article
- The genetics of familial combined hyperlipidaemia.Nature reviews. Endocrinology · 2012Review
- A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.PLoS genetics · 2009Article
- Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2.Diabetologia · 2008Article
- Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism.Circulation research · 2008Article
- Association analysis of allelic variants of USF1 in coronary atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study.Diabetologia · 2008Article
- Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders.Genome research · 2008Article
- USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Positive evidence has been reported for linkage and association between the upstream stimulatory factor 1 gene (USF1) and familial combined hyperlipidemia (FCHL). We genotyped the two most positive single-nucleotide polymorphisms (SNPs) (usf1s1: rs3737787 and usf1s2: rs2073658) from previous studies in a large family sample. This sample included 2,195 subjects in 87 Utah pedigrees ascertained for early death due to coronary heart disease (CHD), early strokes, or early onset hypertension. There were a total of 262 relative pairs in these families with FCHL. In the full family sample, FCHL was associated with usf1s1 (P = 0.02). Triglyceride and LDL cholesterol defined qualitatively or quantitatively were also associated with usf1s1 (P = 0.02-0.05). Results were strengthened for qualitative and quantitative triglyceride and LDL cholesterol when data from males only was analyzed, revealing associations for usf1s1 (P = 0.001-0.02), usf1s2 (P = 0.02-0.05) and the haplotype of these two SNPs (P = 0.01-0.04). The strongest results were in the subset of subjects from families ascertained for premature stroke or hypertension, rather than those ascertained for premature CHD. This study replicates the involvement of USF1 in FCHL and related lipid traits in a family sample not ascertained for FCHL.
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