ReviewSpringer seminars in immunopathology2005
Role of helminths in regulating mucosal inflammation.
Review in Springer seminars in immunopathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 62 citations in OpenAlex.
- Therapeutic Effect ofFrontiers in cell and developmental biology · 2021Article
- Helminth Induced Immunoregulation and Novel Therapeutic Avenue of Allergy.Journal of asthma and allergy · 2020Review
- Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.Gut and liver · 2016Review
- Allergy and worms: let's bring back old friends?Wiener medizinische Wochenschrift (1946) · 2014Review
- Allergic diseases and helminth infections.Pathogens and global health · 2013Review
- Parasitic helminth cystatin inhibits DSS-induced intestinal inflammation via IL-10(+)F4/80(+) macrophage recruitment.The Korean journal of parasitology · 2011Article
- Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity.Gastroenterology · 2011Article
- Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus.Inflammatory bowel diseases · 2010Article
- Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice.World journal of gastroenterology · 2010Article
- Do you have a probiotic in your future?Microbes and infection · 2008Review
- Probiotics and prebiotics in inflammatory bowel disease: microflora 'on the scope'.British journal of clinical pharmacology · 2008Review
- Worms and the treatment of inflammatory bowel disease: are molecules the answer?Clinical & developmental immunology · 2008Review
- The use of Trichuris suis and other helminth therapies to treat Crohn's disease.Parasitology research · 2007Review
- Parasitic worms and inflammatory diseases.Parasite immunology · 2006Review
- Emerging infectious determinants of chronic diseases.Emerging infectious diseases · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid rise in prevalence of ulcerative colitis (UC) and Crohn's disease (CD) in highly developed countries suggests that environmental change engenders risk for inflammatory bowel disease (IBD). Eradication of parasitic worms (helminths) through increased hygiene may be one such change that has led to increased prevalence of these diseases. Helminths alter host mucosal and systemic immunity, inhibiting dysregulated inflammatory responses. Animals exposed to helminths are protected from experimental colitis, encephalitis, and diabetes. Patients with CD or UC improve when exposed to whipworm. Lamina propria (LP) mononuclear cells from helminth-colonized mice make less interleukin (IL)-12 p40 and IFN-gamma, but more IL-4, IL-13, IL-10, TGF-beta, and PGE(2) compared to LP mononuclear cells from naive mice. Systemic immune responses show similar skewing toward Th2 and regulatory cytokine production in worm-colonized animal models and humans. Recent reports suggest that helminths induce regulatory T cell activity. These effects by once ubiquitous organisms may have protected individuals from many of the emerging immune-mediated illnesses like IBD, multiple sclerosis, type I diabetes, and asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.