ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 185 citations in OpenAlex.
- Article
- Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.Journal of computational neuroscience · 2026Article
- NT2-derived astrocyte-neuron co-culture reflects physiological relevance and offers research validity.Cellular & molecular biology letters · 2025Article
- Article
- Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic CaCells · 2024Article
- Voltage- and Calcium-Gated Membrane Currents Tune the Plateau Potential Properties of Multiple Neuron Types.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Excitatory subtypes of the lateral amygdala neurons are differentially involved in regulation of synaptic plasticity and excitation/inhibition balance in aversive learning in mice.Frontiers in cellular neuroscience · 2023Article
- R-type voltage-gated CaCell reports · 2022Article
- Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH.Frontiers in pharmacology · 2022Article
- Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses.Nature communications · 2021Article
- IInternational journal of molecular sciences · 2021Article
- A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit.Scientific reports · 2021Article
- Firing patterns of gonadotropin-releasing hormone neurons are sculpted by their biologic state.Royal Society open science · 2020Article
- Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.JCI insight · 2020Article
- Disruption of GpI mGluR-Dependent Cav2.3 Translation in a Mouse Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Modeling Analysis of Axonal After Potential at Hippocampal Mossy Fibers.Frontiers in cellular neuroscience · 2019Article
- The Slow Depolarization Following Individual Spikes in Thin, Unmyelinated Axons in Mammalian Cortex.Frontiers in cellular neuroscience · 2019Article
- The subthreshold-active KCommunications biology · 2019Article
- The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain.Neuronal signaling · 2018Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Action potentials in pyramidal neurons are typically followed by an afterdepolarization (ADP), which in many cells contributes to intrinsic burst firing. Despite the ubiquity of this common excitable property, the responsible ion channels have not been identified. Using current-clamp recordings in hippocampal slices, we find that the ADP in CA1 pyramidal neurons is mediated by an Ni2+-sensitive calcium tail current. Voltage-clamp experiments indicate that the Ni2+-sensitive current has a pharmacological and biophysical profile consistent with R-type calcium channels. These channels are available at the resting potential, are activated by the action potential, and remain open long enough to drive the ADP. Because the ADP correlates directly with burst firing in CA1 neurons, R-type calcium channels are crucial to this important cellular behavior, which is known to encode hippocampal place fields and enhance synaptic plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.