ArticleClinical and experimental immunology2005
Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus.
Article in Clinical and experimental immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis.BMC oral health · 2019Pooled it
- Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial.Rheumatology international · 2020Trial
- Comparative Effectiveness of Different Probiotic Delivery Methods in Oral Candidiasis: A Systematic Review.Microorganisms · 2025Review
- Review
- A Denture Use Model Associated withJournal of fungi (Basel, Switzerland) · 2022Article
- Effectiveness of Oral Probiotics in ReducingInternational journal of clinical pediatric dentistry · 2022Article
- Protective Effects of the Probiotic BacteriumIranian journal of medical sciences · 2021Article
- Development of Probiotic Formulations for Oral Candidiasis Prevention: Gellan Gum as a Carrier To Deliver Lactobacillus paracasei 28.4.Antimicrobial agents and chemotherapy · 2020Article
- The Dysbiosis and Inter-Kingdom Synergy Model in Oropharyngeal Candidiasis, a New Perspective in Pathogenesis.Journal of fungi (Basel, Switzerland) · 2019Article
- Ecological Therapeutic Opportunities for Oral Diseases.Microbiology spectrum · 2017Review
- Probiotic Bacteria Alter Pattern-Recognition Receptor Expression and Cytokine Profile in a Human Macrophage Model Challenged withFrontiers in microbiology · 2017Article
- Innate Immunity and Saliva in Candida albicans-mediated Oral Diseases.Journal of dental research · 2016Review
- Therapeutic Application of Synbiotics, a Fusion of Probiotics and Prebiotics, and Biogenics as a New Concept for Oral Candida Infections: A Mini Review.Frontiers in microbiology · 2016Review
- New insight into an old concept: role of immature erythroid cells in immune pathogenesis of neonatal infection.Frontiers in immunology · 2014Review
- The patient with sore throat.The Medical clinics of North America · 2010Review
- Influence of probiotics on Candida presence and IgA anti-Candida in the oral cavity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2009Article
- Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of Lactobacillus acidophilus.British journal of sports medicine · 2006Article
- Antimicrobial Efficacy of Probiotic and Herbal Oral Rinses against Candida albicans in Children: A Randomized Clinical Trial.International journal of clinical pediatric dentistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orally administered live Lactobacillus acidophilus was assessed for its capacity to enhance clearance from the oral cavity of DBA/2 mice shown previously to be 'infection prone'. L. acidophilus fed to DBA/2 mice significantly shortened the duration of colonization of the oral cavity compared to controls. Enhanced clearance of Candida albicans correlated with both early mRNA gene expression for interleukin (IL)-4 and interferon (IFN)-gamma and expression of their secreted products in cultures of cervical lymph nodes stimulated with Candida antigen. In addition rapid clearance correlated with higher levels of IFN-gamma and nitric oxide in saliva. Delayed clearance, less pronounced levels of the cytokine response, saliva IFN-gamma and nitric oxide, and later mRNA expression for IL-4 and IFN-gamma relative to feeding with the L. acidophilus isolate were noted in mice fed a different Lactobacillus isolate (L. fermentum). These observations indicate significant variations in individual isolates to activate the common mucosal system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.