ArticleBritish journal of cancer2005
Establishment of an immortalised human ovarian surface epithelial cell line without chromosomal instability.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
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- Targeting Aurora A Kinase (AAK) in Platinum-Resistant High Grade Serous Ovarian Cancer.Frontiers in oncology · 2020Article
- Establishment of an immortalized intestinal epithelial cell line from tree shrews by lentivirus-mediated hTERT gene transduction.Cytotechnology · 2019Article
- MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53.Oncotarget · 2016Article
- Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.Oncotarget · 2016Article
- IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer.British journal of cancer · 2015Article
- Epigenetic determinants of ovarian clear cell carcinoma biology.International journal of cancer · 2014Article
- Culture models to define key mediators of cancer matrix remodeling.Frontiers in oncology · 2014Review
- Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation.Cancer science · 2010Article
- Asian society of gynecologic oncology workshop 2010.Journal of gynecologic oncology · 2010Article
- Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies: a novel insight into the molecular pathogenesis of ovarian epithelial carcinoma.Cancer science · 2010Article
- Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes.Oncogene · 2010Article
- Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression.Cell proliferation · 2007Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial ovarian carcinoma is thought to derive from ovarian surface epithelium (OSE). The black box of the early molecular changes in ovarian carcinogenesis is being interpreted by the development of experimental systems employing immortalised human OSE cells. However, the existing cell lines of the OSE cells have limited utility due to chromosomal instability. Our goal was to establish new immortalised human OSE cells that retain the original characteristics of the primary cells without chromosomal alterations. Using primary human OSE cells obtained from a postmenopausal patient with endometrial cancer, five cell lines ('HOSE1' lines) were newly established by infection with retroviral expression vectors containing type 16 human papillomavirus (HPV-16) E6, E7, a variant E6 (E6delta151), and Bmi1 polycomb gene, in combination with telomerase reverse transcriptase (hTERT). Consequently, five HOSE1s cell lines, HOSE1s-E6/hTERT, -E7/hTERT, -E6/E7/hTERT, -E6delta151/E7/hTERT, and -E6delta151/Bmi1/hTERT, grew beyond the population doubling number of 200. These cell lines, except for HOSE1-E6/hTERT, essentially showed the original features of the primary human OSE cells. Of them, HOSE1-E7/hTERT preserved diploidy in a kariotype analysis, and did not show transformed phenotypes in anchorage-independent growth and tumour formation. Thus, HOSE1-E7/hTERT may provide a novel model system with which to investigate the mechanisms of early molecular changes.
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