ArticleBritish journal of cancer2005
Gene expression signatures for colorectal cancer microsatellite status and HNPCC.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Randomized, open-label, phase 2 study of andecaliximab plus nivolumab versus nivolumab alone in advanced gastric cancer identifies biomarkers associated with survival.Journal for immunotherapy of cancer · 2021Trial
- Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours.Human molecular genetics · 2024Article
- Association of Microsatellite Instability and Gene Expression Profile in Colorectal Carcinoma and Potential Implications for Therapy.Medicina (Kaunas, Lithuania) · 2024Article
- The putative oncogenic role of WDTC1 in colorectal cancer.Carcinogenesis · 2022Article
- Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients.BMC cancer · 2019Article
- Cross-platform Data Analysis Reveals a Generic Gene Expression Signature for Microsatellite Instability in Colorectal Cancer.BioMed research international · 2019Article
- Ezrin expression combined with MSI status in prognostication of stage II colorectal cancer.PloS one · 2017Article
- Review
- DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond.International journal of molecular sciences · 2016Review
- Integrative Omics Analysis Reveals Post-Transcriptionally Enhanced Protective Host Response in Colorectal Cancers with Microsatellite Instability.Journal of proteome research · 2016Article
- Molecular dissection of microsatellite instable colorectal cancer.Cancer discovery · 2013Review
- Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.World journal of gastroenterology · 2012Review
- Villin expression is frequently lost in poorly differentiated colon cancer.The American journal of pathology · 2012Article
- Colorectal adenoma to carcinoma progression is accompanied by changes in gene expression associated with ageing, chromosomal instability, and fatty acid metabolism.Cellular oncology (Dordrecht, Netherlands) · 2012Article
- Identification of pathway deregulation--gene expression based analysis of consistent signal transduction.PloS one · 2012Article
- Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis.BMC genomics · 2011Article
- Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.British journal of cancer · 2011Article
- Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling.The American journal of pathology · 2011Article
- Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan.Journal of biomedical science · 2011Article
- MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers.Cancer research · 2011Article
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of microsatellite instable (MSI) colorectal cancers are sporadic, but a subset belongs to the syndrome hereditary non-polyposis colorectal cancer (HNPCC). Microsatellite instability is caused by dysfunction of the mismatch repair (MMR) system that leads to a mutator phenotype, and MSI is correlated to prognosis and response to chemotherapy. Gene expression signatures as predictive markers are being developed for many cancers, and the identification of a signature for MMR deficiency would be of interest both clinically and biologically. To address this issue, we profiled the gene expression of 101 stage II and III colorectal cancers (34 MSI, 67 microsatellite stable (MSS)) using high-density oligonucleotide microarrays. From these data, we constructed a nine-gene signature capable of separating the mismatch repair proficient and deficient tumours. Subsequently, we demonstrated the robustness of the signature by transferring it to a real-time RT-PCR platform. Using this platform, the signature was validated on an independent test set consisting of 47 tumours (10 MSI, 37 MSS), of which 45 were correctly classified. In a second step, we constructed a signature capable of separating MMR-deficient tumours into sporadic MSI and HNPCC cases, and validated this by a mathematical cross-validation approach. The demonstration that this two-step classification approach can identify MSI as well as HNPCC cases merits further gene expression studies to identify prognostic signatures.
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