ArticleGenetics2005
The [URE3] prion is not conserved among Saccharomyces species.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Protein assembly systems in natural and synthetic biology.BMC biology · 2020Review
- Emergence and evolution of yeast prion and prion-like proteins.BMC evolutionary biology · 2016Article
- Swa2, the yeast homolog of mammalian auxilin, is specifically required for the propagation of the prion variant [URE3-1].Molecular microbiology · 2015Article
- The [URE3] prion in Candida.Eukaryotic cell · 2013Article
- Prions in yeast.Genetics · 2012Review
- Amyloid of the Candida albicans Ure2p prion domain is infectious and has an in-register parallel β-sheet structure.Biochemistry · 2011Article
- Article
- Relationship between prion propensity and the rates of individual molecular steps of fibril assembly.The Journal of biological chemistry · 2011Article
- Prion amyloid structure explains templating: how proteins can be genes.FEMS yeast research · 2010Review
- Distinct type of transmission barrier revealed by study of multiple prion determinants of Rnq1.PLoS genetics · 2010Article
- Characterization of the functional role of nucleotides within the URE2 IRES element and the requirements for eIF2A-mediated repression.RNA (New York, N.Y.) · 2009Article
- The cellular concentration of the yeast Ure2p prion protein affects its propagation as a prion.Molecular biology of the cell · 2009Article
- Article
- Specificity of the J-protein Sis1 in the propagation of 3 yeast prions.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures.BioEssays : news and reviews in molecular, cellular and developmental biology · 2008Review
- Recent advances in nitrogen regulation: a comparison between Saccharomyces cerevisiae and filamentous fungi.Eukaryotic cell · 2008Review
- Prions of fungi: inherited structures and biological roles.Nature reviews. Microbiology · 2007Review
- Article
- Prion species barrier between the closely related yeast proteins is detected despite coaggregation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities.Molecular cell · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The [URE3] prion of Saccharomyces cerevisiae is a self-propagating inactive form of the nitrogen catabolism regulator Ure2p. To determine whether the [URE3] prion is conserved in S. cerevisiae-related yeast species, we have developed genetic tools allowing the detection of [URE3] in Saccharomyces paradoxus and Saccharomyces uvarum. We found that [URE3] is conserved in S. uvarum. In contrast, [URE3] was not detected in S. paradoxus. The inability of S. paradoxus Ure2p to switch to a prion isoform results from the primary sequence of the protein and not from the lack of cellular cofactors as heterologous Ure2p can propagate [URE3] in this species. Our data therefore demonstrate that [URE3] is conserved only in a subset of Saccharomyces species. Implications of our finding on the physiological and evolutionary meaning of the yeast [URE3] prion are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.