Evidence map›Paper›PMID 15956606›Full record

ArticleJournal of virology2005

Whole-genome transcription profiling of rhesus monkey rhadinovirus.

Dirk P Dittmer, Carlos M Gonzalez, Wolfgang Vahrson, Scott M DeWire, Rebecca Hines-Boykin, Blossom Damania

Abstract read
In one paragraph

Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dirk P DittmerDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina 27599, USA.
Carlos M Gonzalez
Wolfgang Vahrson
Scott M DeWire
Rebecca Hines-Boykin
Blossom Damania

Funding

Role of KSHV Viral Proteins in Signaling and PathogenesisR01CA096500 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A · 2002 to 2022
$6.0M
Regulation of the KSHV Latent PromoterR01CA109232 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DITTMER, DIRK P · 2004 to 2014
$2.5M
Genetic system for thesus monkey rhadinovirus (RRV)R03AI058093 · NIAID · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A · 2004 to 2005
$146k
NCI NIH HHS CA096500NCI NIH HHS CA096500-SNCI NIH HHS CA109232NCI NIH HHS R01 CA096500NCI NIH HHS R01 CA109232NIAID NIH HHS AI58093NIAID NIH HHS R03 AI058093
6 · The paper itself

Abstract

Rhesus monkey rhadinovirus (RRV) and Kaposi's sarcoma-associated herpesvirus (KSHV; also called human herpesvirus 8) belong to the gamma-2 grouping of herpesviruses. RRV and KSHV share a high degree of sequence similarity, and their genomes are organized in a similar fashion. RRV serves as an excellent animal model system to study the gamma herpesvirus life cycle both in vitro and in vivo. We have developed a high-sensitivity, high-throughput, high-specificity real-time quantitative reverse transcriptase-based PCR assay for RRV and have used this assay to profile transcription from the whole RRV genome during de novo productive infection of rhesus fibroblasts. Using this assay, we demonstrate that the genome-wide transcription profile for RRV closely parallels the genome-wide transcription profile for KSHV.

Indexed as

Gene Expression ProfilingGenome, ViralAnimalsBase SequenceDNA PrimersMacaca mulattaPolymerase Chain ReactionRhadinovirusSensitivity and SpecificityTranscription, GeneticDNA Primers

Identifiers

PMID15956606
PMCPMC1143716

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.