ArticleJournal of virology2005
Actin is a component of the compensation mechanism in pseudorabies virus virions lacking the major tegument protein VP22.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Proteomic Comparison of Three Wild-Type Pseudorabies Virus Strains and the Attenuated Bartha Strain Reveals Reduced Incorporation of Several Tegument Proteins in Bartha Virions.Journal of virology · 2022Article
- HSV-1 Cytoplasmic Envelopment and Egress.International journal of molecular sciences · 2020Review
- Article
- Alphaherpesvirus Major Tegument Protein VP22: Its Precise Function in the Viral Life Cycle.Frontiers in microbiology · 2020Review
- ORF7 of Varicella-Zoster Virus Is Required for Viral Cytoplasmic Envelopment in Differentiated Neuronal Cells.Journal of virology · 2017Article
- Structural Proteomics of Herpesviruses.Viruses · 2016Review
- Review
- Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradation.PLoS pathogens · 2014Article
- Analysis of the early steps of herpes simplex virus 1 capsid tegumentation.Journal of virology · 2013Article
- Nuclear actin and lamins in viral infections.Viruses · 2012Review
- Tegument Proteins of Kaposi's Sarcoma-Associated Herpesvirus and Related Gamma-Herpesviruses.Frontiers in microbiology · 2012Article
- Deciphering novel host-herpesvirus interactions by virion proteomics.Frontiers in microbiology · 2012Article
- Proteomic characterization of pseudorabies virus extracellular virions.Journal of virology · 2011Article
- Actin in herpesvirus infection.Viruses · 2011Review
- Role of tegument proteins in herpesvirus assembly and egress.Protein & cell · 2010Review
- Herpesvirus interactions with the host cytoskeleton.Journal of virology · 2009Review
- The capsid and tegument of the alphaherpesviruses are linked by an interaction between the UL25 and VP1/2 proteins.Journal of virology · 2007Article
- Electron tomography of nascent herpes simplex virus virions.Journal of virology · 2007Article
- Identification of an essential domain in the herpesvirus VP1/2 tegument protein: the carboxy terminus directs incorporation into capsid assemblons.Journal of virology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Despite being a major component of the pseudorabies virus tegument, VP22 is not required for PRV replication, virulence, or neuroinvasion (T. del Rio, H. C. Werner, and L. W. Enquist, J. Virol. 76:774-782, 2002). In the absence of VP22, tegument assembly compensates in a limited fashion with increased incorporation of cellular actin. Infection of epithelial cell lines expressing fluorescent actin fusion proteins resulted in the incorporation of filamentous and nonfilamentous actin into individual virions that were predominately light, noninfectious particles. We conclude that cellular actin is incorporated in the tegument of wild-type virions and is part of a compensation mechanism for VP22-null virions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.