ArticleJournal of clinical microbiology2005
Shifts of Bordetella pertussis variants in Sweden from 1970 to 2003, during three periods marked by different vaccination programs.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 112 citations in OpenAlex.
- Antibody responses to Bordetella pertussis Fim2 or Fim3 following immunization with a whole-cell, two-component, or five-component acellular pertussis vaccine and following pertussis disease in children in Sweden in 1997 and 2007.Clinical and vaccine immunology : CVI · 2014Trial
- Quantifying the impact of vaccination on pertussis dynamics in Sweden.PLoS computational biology · 2026Article
- Vaccine-induced strain replacement: theory and real-life implications.Future microbiology · 2024Review
- Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity.Vaccines · 2022Review
- Pathogen evolution during vaccination campaigns.PLoS biology · 2022Article
- Anti-vaccination movements in the world and in Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Proteomics of Bordetella pertussis whole-cell and acellular vaccines.BMC research notes · 2019Article
- Surveillance of Circulating Bordetella pertussis Strains in Europe during 1998 to 2015.Journal of clinical microbiology · 2018Article
- Non-Vaccine-Type Human Papillomavirus Prevalence After Vaccine Introduction: No Evidence for Type Replacement but Evidence for Cross-Protection.Sexually transmitted diseases · 2018Article
- Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.Medical microbiology and immunology · 2018Review
- An Extracellular Polysaccharide Locus Required for Transmission of Bordetella bronchiseptica.The Journal of infectious diseases · 2017Article
- The relationship between mucosal immunity, nasopharyngeal carriage, asymptomatic transmission and the resurgence ofF1000Research · 2017Review
- Epidemic cycling in a multi-strain SIRS epidemic network model.Theoretical biology & medical modelling · 2016Article
- Changes in Predominance of Pulsed-Field Gel Electrophoresis Profiles of Bordetella pertussis Isolates, United States, 2000-2012.Emerging infectious diseases · 2016Article
- The pertussis enigma: reconciling epidemiology, immunology and evolution.Proceedings. Biological sciences · 2016Review
- Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.Scientific reports · 2015Article
- Recent trends of antigenic variation in Bordetella pertussis isolates in Korea.Journal of Korean medical science · 2014Article
- Pulsed-field gel electrophoresis analysis of Bordetella pertussis isolates circulating in Europe from 1998 to 2009.Journal of clinical microbiology · 2013Article
- Antibody responses to individual Bordetella pertussis fimbrial antigen Fim2 or Fim3 following immunization with the five-component acellular pertussis vaccine or to pertussis disease.Clinical and vaccine immunology : CVI · 2012Article
- Controlling antimicrobial resistance through targeted, vaccine-induced replacement of strains.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Swedish population of Bordetella pertussis strains was characterized from 1,247 isolates covering a whole-cell vaccine program up to 1979, a 17-year period without vaccination (1979 to 1996), and a period after the introduction of general vaccination among newborns with acellular pertussis vaccines (1997 to 2003). Strains were characterized by serotyping and genotyping of pertactin and ptxA and by means of pulsed-field gel electrophoresis (PFGE). With emphasis on vaccine-related markers, the vast majority of circulating strains were of nonvaccine type. There were shifts of serotype connected with shifts of vaccination program. Serotype Fim3 was most frequent during the periods with general vaccination schedules, whereas serotype Fim2 was predominant during the 17-year vaccine-free period. Pertactin 1 was predominant during the pertussis whole-cell (Pw) vaccine period but was thereafter replaced by prn2 and has not reappeared after the introduction of acellular pertussis (Pa) vaccines. ptxA (1) was predominant over all three decades. There was a significant difference in the distribution of serotypes between vaccinated and unvaccinated individuals, but not for pertactin. A few PFGE profiles were predominant over the years: BpSR25 (serotype Fim3 prn1/7) and BpSR18 (serotype Fim3 prn2) during the Pw period, BpSR1 (serotype Fim2 prn2) during the 17 years without general vaccination, and BpSR11 (serotype Fim3 prn2) after the reintroduction of general vaccination in 1996. Despite differences between the pertactin and toxin types of Pa vaccines and circulating strains, there is no evidence that there is a threat, i.e., the vaccination program so far has been effective against whooping cough, and there seems to be no impact on the effectiveness of the vaccination program from the bacterial polymorphism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.