ArticleJournal of clinical microbiology2005
Community-wide outbreaks of clonally related CTX-M-14 beta-lactamase-producing Escherichia coli strains in the Calgary health region.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 141 citations in OpenAlex.
- Genomic Characterization and Antimicrobial Resistance of ESBL-Producing,Infection and drug resistance · 2025Article
- Spatial, Ecologic, and Clinical Epidemiology of Community-Onset, Ceftriaxone-Resistant Enterobacteriaceae, Cook County, Illinois, USA.Emerging infectious diseases · 2021Article
- Photocatalytic, Bactericidal and Molecular Docking Analysis of Annealed Tin Oxide Nanostructures.Nanoscale research letters · 2021Article
- Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production - a threat around the world.Heliyon · 2020Review
- Phenotypic and genotypic characterization of multi-drug-resistantInfection and drug resistance · 2019Article
- Article
- Escherichia coli ST131-mBio · 2018Article
- Extended spectrum beta lactamase producing organisms causing urinary tract infections in Sri Lanka and their antibiotic susceptibility pattern -A hospital based cross sectional study.BMC infectious diseases · 2017Article
- Antimicrobial Resistance and Molecular Epidemiology of ESBL-ProducingFrontiers in microbiology · 2017Article
- Urinary tract infections attributed to diverse ExPEC strains in food animals: evidence and data gaps.Frontiers in microbiology · 2015Article
- Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment.Saudi journal of biological sciences · 2015Article
- Community-associated extended-spectrum β-lactamase-producing Escherichia coli infection in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Comparative analysis of ESBL-positive Escherichia coli isolates from animals and humans from the UK, The Netherlands and Germany.PloS one · 2013Article
- Food and human gut as reservoirs of transferable antibiotic resistance encoding genes.Frontiers in microbiology · 2013Article
- Foodborne urinary tract infections: a new paradigm for antimicrobial-resistant foodborne illness.Frontiers in microbiology · 2013Article
- Prevalence and pathogenesis of extended-spectrum beta-lactamase producing Escherichia coli causing urinary tract infection in hospitalized patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Comparative epidemiology of CTX-M-14 and CTX-M-15 producing Escherichia coli: association with distinct demographic groups in the community in New Zealand.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- First description of Escherichia coli producing CTX-M-15- extended spectrum beta lactamase (ESBL) in out-patients from south eastern Nigeria.Annals of clinical microbiology and antimicrobials · 2012Article
- Is Escherichia coli urinary tract infection a zoonosis? Proof of direct link with production animals and meat.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Chicken as reservoir for extraintestinal pathogenic Escherichia coli in humans, Canada.Emerging infectious diseases · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs) typically cause nosocomial infections. Previous surveillance in the Calgary Health Region showed that Escherichia coli strains producing ESBLs were common among community patients. During the period (2000 to 2002): 23 of 157 (15%) of the strains were positive for blaCTX-M genes from the CTX-M-I group (CTX-M-1-like) and 87 of 157 (55%) of the strains were positive for blaCTX-M genes from the CTX-M-III group (CTX-M-14-like). The objective of this study was to investigate the molecular epidemiology of these strains. The beta-lactamases were characterized, and the genetic relatedness of the isolates was analyzed by digesting genomic DNA with the restriction endonuclease XbaI and by performing pulse-field gel electrophoresis (PFGE). PFGE revealed two closely related restriction patterns (clusters CTXM14A and CTXM14AR) among 67 (77%) CTX-M-14 producers. These strains from CTXM14A had nearly identical susceptibility patterns and were isolated most often from urine samples obtained at community sites during 2000 and 2001. Strains from the CTX-M-1-like and CTX-M-negative groups were unrelated to clusters CTXM14, CTXM14AR, and CTXM14NR. We conclude that clonally related strains of E. coli producing CTX-M-14 beta-lactamases were responsible for a predominantly community-wide outbreak. Further studies are warranted to investigate whether community-onset diseases caused by ESBL-producing E. coli are related to a point source or transmission within the community.
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