ArticleJournal of clinical microbiology2005
Comparison of Campylobacter jejuni lipooligosaccharide biosynthesis loci from a variety of sources.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 134 citations in OpenAlex.
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- Zoonotic Transmission ofFrontiers in microbiology · 2022Article
- Molecular and in silico typing of the lipooligosaccharide biosynthesis gene cluster in Campylobacter jejuni and Campylobacter coli.PloS one · 2022Article
- Biomolecule sulphation and novel methylations related to Guillain-Barré syndrome-associatedMicrobial genomics · 2021Article
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- Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans.Communications biology · 2021Article
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- High prevalence of Campylobacter jejuni CC21 and CC257 clonal complexes in children with gastroenteritis in Tehran, Iran.BMC infectious diseases · 2021Article
- Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations ofFrontiers in microbiology · 2021Article
- Genomic Relatedness, Antibiotic Resistance and Virulence Traits ofFrontiers in microbiology · 2021Article
- Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon.PLoS neglected tropical diseases · 2020Article
- Virulence Traits of InpatientMicroorganisms · 2020Article
- Differential Distribution of theMicroorganisms · 2020Article
- An Updated Classification System and Review of the Lipooligosaccharide Biosynthesis Gene Locus inFrontiers in microbiology · 2020Review
- Distribution of genes related to Type 6 secretion system and lipooligosaccharide that induced ganglioside mimicry amongGut pathogens · 2020Article
- RevisitingFrontiers in cellular and infection microbiology · 2020Review
- Bacterial ABNature communications · 2019Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni strains exhibit significant variation in the genetic content of the lipooligosaccharide (LOS) biosynthesis loci with concomitant differences in LOS structure. The C. jejuni LOS loci have been grouped into six classes based on gene content and organization. Utilizing PCR amplifications of genes from these loci, we were able to classify a majority (80%) of the LOS biosynthesis loci from 123 strains of C. jejuni that included 39 of the Penner serotype reference strains. We found that a particular LOS class was not always associated with a specific Penner serotype, and 14 of 16 Guillain-Barré syndrome-associated isolates tested in this study shared the same LOS class. The remaining isolates that could not be classified were often distinguishable from each other based on the results of gene-specific PCR and the lengths of their LOS biosynthesis loci as determined by long (XL) PCR. Sequence analysis of two of these unique XL PCR products demonstrated two new LOS classes. These results support the hypothesis that the LOS locus is a hot spot for genetic exchange and rearrangements. Analysis of the LOS biosynthesis genes by PCR assays can be used for typing C. jejuni and offers the advantage of inferring potential LOS structures.
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