ArticleThe Journal of biological chemistry2005
Down-regulation of 7SL RNA expression and impairment of vesicular protein transport pathways by Leishmania infection of macrophages.
Article in The Journal of biological chemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Non-coding RNAs as emerging players inFrontiers in cellular and infection microbiology · 2025Article
- The paradigm of intracellular parasite survival and drug resistance in leishmanial parasite through genome plasticity and epigenetics: Perception and future perspective.Frontiers in cellular and infection microbiology · 2023Review
- Functional Intricacy and Symmetry of Long Non-Coding RNAs in Parasitic Infections.Frontiers in cellular and infection microbiology · 2021Review
- Model-based Evaluation of Gene Expression Changes in Response toGene regulation and systems biology · 2019Review
- Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever GroupFrontiers in cellular and infection microbiology · 2019Article
- Review
- Exploiting Long Noncoding RNAs as Pharmacological Targets to Modulate Epigenetic Diseases.The Yale journal of biology and medicine · 2017Review
- Involvement of RNA Polymerase III in Immune Responses.Molecular and cellular biology · 2015Article
- Changes in Macrophage Gene Expression Associated with Leishmania (Viannia) braziliensis Infection.PloS one · 2015Article
- Article
- Heat shock factor binding in Alu repeats expands its involvement in stress through an antisense mechanism.Genome biology · 2011Article
- Leishmania-induced repression of selected non-coding RNA genes containing B-box element at their promoters in alternatively polarized M2 macrophages.Molecular and cellular biochemistry · 2011Article
- Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania.The Journal of biological chemistry · 2011Article
- Macrophage and T-cell gene expression in a model of early infection with the protozoan Leishmania chagasi.PLoS neglected tropical diseases · 2008Article
- 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G.Journal of virology · 2007Article
- Leishmania major abrogates gamma interferon-induced gene expression in human macrophages from a global perspective.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The parasitic protozoan Leishmania specifically manipulates the expression of host macrophage genes during initial interactions, as revealed by mRNA differential display reverse transcription-PCR and cDNA microarray analyses. The genes that are down-regulated in mouse (J774G8) or human (U937) macrophages upon exposure to Leishmania include small RNA transcripts from the short interspersed element sequences. Among the short interspersed element RNAs that are down-regulated is 7SL RNA, which is the RNA component of the signal recognition particle. Because the microbicidal functions of macrophages profoundly count on vesicular protein transport processes, down-regulation of 7SL RNA may be significant in the establishment of infection by Leishmania in macrophage phagolysosomes. To evaluate whether down-regulation of 7SL RNA results in inhibition of signal recognition particle-mediated vesicular protein transport processes, we have tested and found that the targeting of proteins to the endoplasmic reticulum and plasma membrane and the secretion of proteins by macrophages are compromised in Leishmania-infected J774G8 and U937 cells. Knocking down 7SL RNA using small interfering RNA mimicked the effect of exposure of macrophages to Leishmania. The overexpression of 7SL RNA in J774G8 or U937 cells made these cells resistant to Leishmania infection, suggesting the possible biological significance of down-regulation of 7SL RNA synthesis in the establishment of infection by Leishmania. We conclude that Leishmania down-regulates 7SL RNA in macrophages to manipulate the targeting of many proteins that use the vesicular transport pathway and thus favors its successful establishment of infection in macrophages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.