ArticleGut2005
Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Meta-analysis of associations between DLG5 R30Q and P1371Q polymorphisms and susceptibility to inflammatory bowel disease.Scientific reports · 2016Pooled it
- Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.International journal of colorectal disease · 2012Pooled it
- Contribution of the IBD5 locus to inflammatory bowel disease: a meta-analysis.Human genetics · 2011Pooled it
- PROBIOTIC APPROACHES FOR TARGETING INFLAMMATORY BOWEL DISEASE: AN UPDATE ON ADVANCES AND OPPORTUNITIES IN MANAGING THE DISEASE.International journal of probiotics & prebiotics · 2016Article
- Article
- The role of heredity in pterygium development.International journal of ophthalmology · 2014Review
- Role of genetics in the diagnosis and prognosis of Crohn's disease.World journal of gastroenterology · 2012Review
- PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites.PloS one · 2012Article
- Role of genetics in the diagnosis and prognosis of Crohn's disease.World journal of gastroenterology · 2011Review
- Haplotype in the IBD5 region is associated with refractory Crohn's disease in Slovenian patients and modulates expression of the SLC22A5 gene.Journal of gastroenterology · 2011Article
- The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants.PloS one · 2010Article
- The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn's disease independent of the IL23R genotype.Journal of gastroenterology · 2010Article
- Is the disease course predictable in inflammatory bowel diseases?World journal of gastroenterology · 2010Article
- Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?Seminars in immunopathology · 2010Review
- Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Pharmacological reviews · 2010Review
- Crohn's disease: an immune deficiency state.Clinical reviews in allergy & immunology · 2010Review
- IGR2096a_1 T and IGR2198a_1 C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn's disease in Hungarian patients.International journal of colorectal disease · 2009Article
- OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease.World journal of gastroenterology · 2008Article
- The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction network.Journal of molecular medicine (Berlin, Germany) · 2008Article
- Inflammatory bowel disease: genetic and epidemiologic considerations.World journal of gastroenterology · 2008Review
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Authors and funding
20 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsRecent data suggest identification of causal genetic variants for inflammatory bowel disease in the DLG5 gene and in the organic cation transporter (OCTN) cluster, both situated in previously described linkage regions. PATIENTS AND
methodsThe polymorphisms in DLG5 (113 G-->A, 4136 C-->A, and DLG5_e26), SLC22A4 (1672 C-->T), and SLC22A5 (-207 G-->C) were assessed in 625 patients with Crohn's disease (CD), 363 patients with ulcerative colitis (UC), and 1012 healthy controls. Association with disease susceptibility, clinical phenotypes, and possible genetic interactions of these polymorphisms with disease associated CARD15/NOD2 mutations was analysed.
resultsNo significant association of DLG5 polymorphisms with CD or UC was observed. Homozygosity for the OCTN-TC haplotype was associated with an increased CD risk (OR = 1.65), which was even greater in the presence of CARD15 mutations. Genotype-phenotype analysis revealed that this association was particularly strong in patients with colonic disease. The TC haplotype was associated with non-fistulising non-fibrostenotic disease, an earlier age of disease onset, and reduced need for surgery.
conclusionOur observations argue against a role of DLG5 polymorphisms in the susceptibility for inflammatory bowel disease, whereas the OCTN polymorphisms are associated with CD. However, due to the comparable weak association observed herein, extended linkage disequilibrium analyses of these variants with the IBD5 haplotype tagged single nucleotide polymorphims might be advisable before definitive conclusions about their causative role in CD can be drawn.
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