Evidence map›Paper›PMID 15955015›Full record

ArticleAddiction (Abingdon, England)2005

The relationship between non-injection drug use behaviors on progression to AIDS and death in a cohort of HIV seropositive women in the era of highly active antiretroviral therapy use.

Farzana Kapadia, Judith A Cook, Marge H Cohen, Nancy Sohler, Andrea Kovacs, Ruth M Greenblatt, Imtiaz Choudhary, David Vlahov

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Addiction (Abingdon, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Article
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  6. Article
  7. Stimulant Use and Viral Suppression in the Era of Universal Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2019
    Article
  8. Article
  9. Article
  10. Humanized mice for HIV and AIDS research.Current opinion in virology · 2016
    Review
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Farzana KapadiaCenter for Urban Epidemiologic Studies, New York Academy of Medicine, New York, NY 10029, USA. fkapadia@nyam.org
Judith A Cook
Marge H Cohen
Nancy Sohler
Andrea Kovacs
Ruth M Greenblatt
Imtiaz Choudhary
David Vlahov
FrontLine Service · USNew York Academy of Medicine · USAlbert Einstein College of Medicine · USJohn H. Stroger, Jr. Hospital of Cook County · USSouthern California University for Professional Studies · USUniversity of California, San Francisco · US

Funding

Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
WELFARE REFORM AND THE PERINATAL HEALTH OF IMMIGRANTSM01RR000083 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$21.1M
NATURAL HISTORY OF HIV INFECTION IN INJECTION DRUG USERSR37DA004334 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 1997 to 2006
$9.0M
THE NATURAL HISTORY OF HIV INFECTION AMONG DRUG USERSR01DA004334 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 1987 to 2011
$7.6M
HCV and Progression of HIV and HAART Response in WomenR01AI052065 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KOVACS, ANDREA A.Z. · 2002 to 2011
$6.9M
NCRR NIH HHS M01 RR000079NCRR NIH HHS M01 RR000083NCRR NIH HHS M01-RR00079NCRR NIH HHS M01-RR00083NIAID NIH HHS R01 AI052065NIAID NIH HHS R56 AI052065NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01-AI-31834NIAID NIH HHS U01-AI-34989NIAID NIH HHS U01-AI-34993NIAID NIH HHS U01-AI-34994NIAID NIH HHS U01-AI-35004NIAID NIH HHS U01-AI-42590NICHD NIH HHS U01 HD032632NICHD NIH HHS U01-HD-32632NIDA NIH HHS DA 04334NIDA NIH HHS R01 DA004334NIDA NIH HHS R37 DA004334NIDA NIH HHS R56 DA004334
6 · The paper itself

Abstract

aimsTo evaluate the effects of longitudinal patterns and types of non-injection drug use (NIDU) on HIV progression in the highly active antiretroviral therapy (HAART) era.

designWomen's Interagency HIV Study (WIHS), a prospective cohort study conducted at six US sites.

methodsData were collected semi-annually from 1994 to 2002 on 1046 HIV(+) women. Multivariate Cox proportional hazards modeling was used to estimate relative hazards for developing AIDS and for death by pattern and type of NIDU.

findingsDuring follow-up, 285 AIDS events and 287 deaths, of which 177 were AIDS-related, were reported. At baseline, consistent and former NIDU was associated with CD4(+) counts of < 200 cells/microl (43% and 46%, respectively) and viral load > 40,000 copies/ml (53% and 55%, respectively). Consistent NIDU reported less HAART use (53%) compared with other NIDU patterns. Stimulant use was associated with CD4(+) cell counts of < 200 cells/microl (53%) and lower HAART initiation (63%) compared with other NIDU types. In multivariate analyses, progression to AIDS was significantly higher among consistent (RH = 2.52), inconsistent (RH = 1.63) and former (RH = 1.56) users compared with never users; and for stimulant (RH = 2.04) and polydrug (RH = 1.65) users compared with non-users. Progression to all-cause death was higher only among former users (RH = 1.48) compared with never users in multivariate analysis. NIDU behaviors were not associated with progression to AIDS-related death.

conclusionsIn this study, pattern and type of NIDU were associated with HIV progression to AIDS and all-cause mortality. These differences were associated with lower HAART utilization among consistent NIDU and use of stimulants, and poor baseline immunological and virological status among former users.

Indexed as

Acquired Immunodeficiency SyndromeAdultAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCohort StudiesDisease ProgressionFemaleHIV SeropositivityHumansMiddle AgedProportional Hazards ModelsProspective StudiesSubstance-Related Disorders

Identifiers

PMID15955015
PMCPMC3128378
OpenAlexW2068167730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.