ArticleJournal of Korean medical science2005
Direct and indirect effects of androgens on survival of hematopoietic progenitor cells in vitro.
Article in Journal of Korean medical science, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis.The Journal of clinical endocrinology and metabolism · 2010Trial
- Association between circulating CD34-positive cell count and height loss among older men.Scientific reports · 2022Article
- Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex.Biomedical reports · 2021Article
- Comparable Effects of the Androgen Derivatives Danazol, Oxymetholone and Nandrolone on Telomerase Activity in Human Primary Hematopoietic Cells from Patients with Dyskeratosis Congenita.International journal of molecular sciences · 2020Article
- Effect of testosterone and hypoxia on the expansion of umbilical cord blood CD34Experimental and therapeutic medicine · 2017Article
- Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.Environmental geochemistry and health · 2016Article
- The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones.International journal of endocrinology · 2015Review
- Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes.Asian journal of andrology · 2013Review
- Do fat supplements increase physical performance?Nutrients · 2013Review
- Hypogonadism in the aging male diagnosis, potential benefits, and risks of testosterone replacement therapy.International journal of endocrinology · 2012Article
- Gender dimorphisms in progenitor and stem cell function in cardiovascular disease.Journal of cardiovascular translational research · 2010Review
- Advances in the understanding of dyskeratosis congenita.British journal of haematology · 2009Review
- Oral oxymetholone reduces mortality induced by gamma irradiation in mice through stimulation of hematopoietic cells.Molecular and cellular biochemistry · 2006Article
- Sex steroids and stem cell function.Molecular medicine (Cambridge, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Androgens remain a common treatment for certain type of anemia, based upon its myelostimulating effects; however, it has not been established whether androgens affect apoptosis of hematopoietic progenitor cells (HPCs). We investigated the effects of the androgens, such as testosterone, 5beta-dihydrotestosterone (5-DHT), and oxymetholone, on apoptosis of normal hematopoietic progenitor cells in vitro. Androgens did not rescue normal bone marrow (BM) CD34+ cells and colony-forming cells (CFCs), other than mature erythroid CFCs, from apoptosis induced by serum- and growth factor deprivation. Oxymetholone did not affect growth factor-mediated survival of normal CD34+ cells or its inhibition by interferon-gamma (IFN-gamma). In a standard methylcellulose clonogenic assay, low concentrations of oxymetholone and 5-DHT stimulated the clonal growth of colony-forming unit (CFU)-erythroid, but did not affect growth of CFU-granulocyte/macrophage or burst-forming unit-erythroid. Oxymetholone and 5-DHT stimulated the production of stem cell factor in normal bone marrow stromal cells (BMSCs) via transcriptional regulation. In agreement with this, oxymetholone-treated BMSCs better supported the survival of HPCs. These data indicate that survival-enhancing or growth-stimulatory effects of androgens on hematopoietic progenitor cells are minimal and mostly restricted to mature erythroid progenitors, and its myelostimulating effects could be attributed, at least in part, to the stimulation of production of hematopoietic growth factors in BMSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.