ReviewMolecular neurobiology2005
Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury.
Review in Molecular neurobiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.Molecular psychiatry · 2013Pooled it
- A Review of the Potential Use of Antioxidants in Spinal Cord Injuries.Antioxidants (Basel, Switzerland) · 2025Review
- Virus-Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses.Frontiers in microbiology · 2021Review
- Fingolimod (FTY720) Preserves High Energy Phosphates and Improves Cardiac Function in Heterotopic Heart Transplantation Model.International journal of molecular sciences · 2020Article
- Article
- Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington's Disease.Frontiers in neuroanatomy · 2017Article
- Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach.Cell reports · 2016Article
- Association of three SNPs in the PARP-1 gene with Hashimoto's thyroiditis.Human genome variation · 2014Article
- Spatial normalization of reverse phase protein array data.PloS one · 2014Article
- Article
- Poly(ADP-ribose) polymerase-1 in amyloid beta toxicity and Alzheimer's disease.Molecular neurobiology · 2012Review
- Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.Journal of enzyme inhibition and medicinal chemistry · 2011Article
- Lipoxygenases and poly(ADP-ribose) polymerase in amyloid beta cytotoxicity.Neurochemical research · 2011Article
- The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Poly(ADP-ribose) metabolism in brain and its role in ischemia pathology.Molecular neurobiology · 2010Review
- Towards a dynamical network view of brain ischemia and reperfusion. Part I: background and preliminaries.Journal of experimental stroke & translational medicine · 2010Article
- Nicotinamide overload may play a role in the development of type 2 diabetes.World journal of gastroenterology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly(ADP-ribose) polymerase (PARP)-1 is a DNA nick sensor that transforms ADP-ribose from betaNAD+ in the form of polymer to over 40 nuclear proteins, particularly to histones, several transcription factors, and PARP itself, modulating their activities and functions. PARP-1 activated by DNA breaks facilitates transcription, replication, and DNA base excision repair. The last studies indicate that PARP-1 is the new nuclear target for fast signals evoked in cell membranes by depolarization and cholinergic and glutaminergic receptors stimulation. Excessive activation of PARP-1 by peroxynitrate-evoked DNA damage during oxidative stress can cause cell death by NAD+/ATP depletion after ischemia-reperfusion injury, inflammation, and diabetes mellitus. The PARP-1 through interaction with nuclear factor-kappaB, p53, and other transcription factors might significantly modulate cell survival and death and a type of death pathway. The pharmacological modulation of PARP-1 might offer a new effective approach for neuroprotection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.