ArticleBrain research. Molecular brain research2005
Gene array profiling of large hypothalamic CNS regions in lactating and randomly cycling virgin mice.
Article in Brain research. Molecular brain research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior.Brain sciences · 2021Review
- Maternal Experience Leads to Lasting Gene Expression Changes in Some Regions of the Mouse Brain.G3 (Bethesda, Md.) · 2019Article
- Down-regulation of fatty acid binding protein 7 (Fabp7) is a hallmark of the postpartum brain.Journal of chemical neuroanatomy · 2018Article
- Genetic and neuroendocrine regulation of the postpartum brain.Frontiers in neuroendocrinology · 2016Review
- Histone deacetylase inhibition induces long-lasting changes in maternal behavior and gene expression in female mice.Endocrinology · 2014Article
- Genes showing altered expression in the medial preoptic area in the highly social maternal phenotype are related to autism and other disorders with social deficits.BMC neuroscience · 2014Article
- Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.PloS one · 2014Article
- Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens.Frontiers in behavioral neuroscience · 2014Article
- Article
- Experience-facilitated improvements in pup retrieval; evidence for an epigenetic effect.Hormones and behavior · 2012Article
- Gene expression changes in the septum: possible implications for microRNAs in sculpting the maternal brain.PloS one · 2012Article
- Increased PTHrP and decreased estrogens alter bone turnover but do not reproduce the full effects of lactation on the skeleton.Endocrinology · 2010Article
- Altered gene expression in mice selected for high maternal aggression.Genes, brain, and behavior · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
A dramatic example of neuronal and physiological plasticity in adult mammals occurs during the transition from a non-maternal to a maternal, lactating state. In this study, we compared gene expression within a large continuous region of the CNS involved in maternal behaviors (hypothalamus, preoptic regions, and nucleus accumbens) between lactating (L) (postpartum Day 7) and randomly cycling virgin (V) outbred mice. Using high-density oligonucleotide arrays representing 11,904 genes, two statistical algorithms were used to identify significant differences in gene expression: robust multiarray (P < 0.001) (n = 92 genes) and significance analysis of microarrays using a 10% false discover rate (n = 114 genes). 27 common genes were identified as significant using both techniques. A subset of genes (n = 5) were selected and examined by real-time PCR. Our findings were consistent with previous published work. For example, neuropeptide Y (NPY) and proenkephalin were elevated in L mice, whereas POMC was decreased. Increased levels of NPY Y2 receptor and polo-like kinase and decreased levels of endothelin receptor type b in L mice are examples of novel gene expression changes not previously identified. Expression differences occurred in broad classes. Together, our findings provide possible new material on gene expression changes that may support maternal behaviors. The advantages and drawbacks of sampling large CNS regions using arrays are discussed.
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