ReviewPflugers Archiv : European journal of physiology2005
TRPV4 as osmosensor: a transgenic approach.
Review in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- Chemosensory Pathways Involved in the Perception of Tomato-Derived Flavonoids and Alkaloids inPathogens (Basel, Switzerland) · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Piezo1, the new actor in cell volume regulation.Pflugers Archiv : European journal of physiology · 2024Review
- General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRP channels and visceral pain.Frontiers in physiology · 2023Article
- TRPV4: A trigger of pathological RhoA activation in neurological disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- Piezo1-Pannexin1 complex couples force detection to ATP secretion in cholangiocytes.The Journal of general physiology · 2021Article
- Implications of Transient Receptor Potential Cation Channels in Migraine Pathophysiology.Neuroscience bulletin · 2021Review
- Hypo-Osmotic Loading Induces Expression of IL-6 in Nucleus Pulposus Cells of the Intervertebral Disc Independent of TRPV4 and TRPM7.Frontiers in pharmacology · 2020Article
- AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage.APL bioengineering · 2019Article
- When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor.The Journal of physiology · 2017Article
- Ocular transient receptor potential channel function in health and disease.BMC ophthalmology · 2015Review
- Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium.Experimental eye research · 2015Article
- Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.Pflugers Archiv : European journal of physiology · 2015Article
- The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding.The Journal of general physiology · 2014Article
- Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.Biochemistry · 2012Article
- Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells.Histochemistry and cell biology · 2012Article
- Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.Arthritis and rheumatism · 2010Article
- Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Transient receptor potential vanilloid channels in hypertension, inflammation, and end organ damage: an imminent target of therapy for cardiovascular disease?Current opinion in cardiology · 2008Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transient receptor potential vanilloid 4 (TRPV4) ion channel was named initially vanilloid-receptor-related osmotically activated channel (VR-OAC). Preliminary answers to the question, "What is the function of the trpv4 gene in live animals ?" are highlighted briefly in this review. In trpv4 null mice, TRPV4 is necessary for the maintenance of osmotic equilibrium, and in Caenorhabditis elegans transgenic for mammalian TRPV4, TRPV4 directs the osmotic avoidance response in the context of the ASH "nociceptive" neuron. The molecular mechanisms of gating of TRPV4 in vivo need to be determined; in particular, whether TRPV4 in live animals is gated via phosphorylation of defined amino-acid residues or more directly through the osmotic stimulus itself.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.