ArticleInternational journal of colorectal disease2006
Selective effect of infliximab on the inflammatory component of a colonic stricture in Crohn's disease.
Article in International journal of colorectal disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pooled it
- Canadian Association of Gastroenterology Clinical Practice Guidelines: The use of tumour necrosis factor-alpha antagonist therapy in Crohn's disease.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2009Guideline
- Endoscopic Management of Strictures in Crohn's Disease: An Unsolved Case.Journal of clinical medicine · 2024Review
- Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts.Gastroenterology · 2023Article
- The Molecular Mechanism of Transforming Growth Factor-β Signaling for Intestinal Fibrosis: A Mini-Review.Frontiers in pharmacology · 2019Review
- Endoscopic management of Crohn's strictures.World journal of gastroenterology · 2018Review
- Fecal calprotectin for detection of postoperative endoscopic recurrence in Crohn's disease: systematic review and meta-analysis.Therapeutic advances in gastroenterology · 2018Article
- Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases.Gastroenterology · 2017Review
- Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD.United European gastroenterology journal · 2016Review
- Multidisciplinary management of gastrointestinal fibrotic stenosis in Crohn's disease.Digestive diseases and sciences · 2015Review
- Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitis-associated fibrosis.Cellular and molecular gastroenterology and hepatology · 2015Article
- Serial intralesional injections of infliximab in small bowel Crohn's strictures are feasible and might lower inflammation.United European gastroenterology journal · 2014Article
- Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin?World journal of gastrointestinal pathophysiology · 2013Review
- Altered molecular pattern of mucosal healing in Crohn's disease fibrotic stenosis.World journal of gastrointestinal pathophysiology · 2013Article
- Potent suppression of arginase 1 expression in murine macrophages by low dose endotoxin.American journal of clinical and experimental immunology · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although infliximab has been shown to improve the clinical course of Crohn's disease, its effect on intestinal strictures is controversial. We describe the case of a woman with steroid-resistant colonic Crohn's disease presenting with intermittent obstruction because of a tight stricture in the splenic flexure. Compared with uninvolved areas, biopsies showed intense edema and inflammatory cell infiltration and immunohistochemistry revealed an excess of TNF-alpha. Her symptoms responded promptly (CDAI went from 444 to 168) to an infliximab infusion (10 mg kg(-1) BW), which also had a dramatic effect on the stricture, now presenting radiologically as a moderate residual, apparently fibrotic, narrowing of the lumen. Endoscopy and histology confirmed the resolution of inflammation and TNF-alpha virtually disappeared. The patient refused additional infusions and after a few months the disease recurred with features identical to the pre-treatment phase. She then opted for surgery. Histology of the resected strictured colon revealed edema, inflammation, and fibrosis, with TNF-alpha back to pre-treatment levels. This case indicates that, in the colon, infliximab specifically relieves the TNF-alpha-mediated inflammatory component of the stricture while having no effect on fibrosis and suggests that the response to infliximab treatment may depend on the nature of the, stricture itself.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.