ReviewInternational journal of biological sciences2005
Dissecting Nck/Dock signaling pathways in Drosophila visual system.
Review in International journal of biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- Downregulation of Nck1 After Spinal Cord Injury in Adult RatsBalkan medical journal · 2022Article
- Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.Neurotoxicity research · 2016Article
- Integration of linear and dendritic actin nucleation in Nck-induced actin comets.Molecular biology of the cell · 2016Article
- A novel interaction between the SH2 domain of signaling adaptor protein Nck-1 and the upstream regulator of the Rho family GTPase Rac1 engulfment and cell motility 1 (ELMO1) promotes Rac1 activation and cell motility.The Journal of biological chemistry · 2014Article
- Stoichiometry of Nck-dependent actin polymerization in living cells.The Journal of cell biology · 2012Article
- A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells.Molecular cell · 2009Article
- PAK thread from amoeba to mammals.Journal of cellular biochemistry · 2009Review
- Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.The Journal of biological chemistry · 2008Article
- Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A convergently regulate the synaptic ratio of ionotropic glutamate receptor subclasses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.Genes & development · 2007Article
- Article
- Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy.The EMBO journal · 2007Article
- Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The establishment of neuronal connections during embryonic development requires the precise guidance and targeting of the neuronal growth cone, an expanded cellular structure at the leading tip of a growing axon. The growth cone contains sophisticated signaling systems that allow the rapid communication between guidance receptors and the actin cytoskeleton in generating directed motility. Previous studies demonstrated a specific role for the Nck/Dock SH2/SH3 adapter protein in photoreceptor (R cell) axon guidance and target recognition in the Drosophila visual system, suggesting strongly that Nck/Dock is one of the long-sought missing links between cell surface receptors and the actin cytoskeleton. In this review, I discuss the recent progress on dissecting the Nck/Dock signaling pathways in R-cell growth cones. These studies have identified additional key components of the Nck/Dock signaling pathways for linking the receptor signaling to the remodeling of the actin cytoskeleton in controlling growth-cone motility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.