ArticleInternational journal of biological sciences2005
No more than 14: the end of the amphioxus Hox cluster.
Article in International journal of biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 71 citations in OpenAlex.
- Evolutionary plasticity in nematode Hox gene complements and genomic loci arrangement.Scientific reports · 2024Article
- Physical Laws Shape Up HOX Gene Collinearity.Journal of developmental biology · 2021Review
- A Preliminary Single-Cell RNA-Seq Analysis of Embryonic Cells That ExpressFrontiers in cell and developmental biology · 2021Article
- Molecular cytogenetic differentiation of paralogs of Hox paralogs in duplicated and re-diploidized genome of the North American paddlefish (Polyodon spathula).BMC genetics · 2017Article
- The role of self-organization in developmental evolution.Theory in biosciences = Theorie in den Biowissenschaften · 2014Article
- Article
- Evolutionary constraints favor a biophysical model explaining hox gene collinearity.Current genomics · 2013Article
- Article
- Evolution of anterior Hox regulatory elements among chordates.BMC evolutionary biology · 2011Article
- Article
- Coordinated spatial and temporal expression of Hox genes during embryogenesis in the acoel Convolutriloba longifissura.BMC biology · 2009Article
- Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters.BMC evolutionary biology · 2008Article
- Deciphering deuterostome phylogeny: molecular, morphological and palaeontological perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- Analysis of the Tribolium homeotic complex: insights into mechanisms constraining insect Hox clusters.Development genes and evolution · 2008Article
- Pre-bilaterian origins of the Hox cluster and the Hox code: evidence from the sea anemone, Nematostella vectensis.PloS one · 2007Article
- PhyloPat: phylogenetic pattern analysis of eukaryotic genes.BMC bioinformatics · 2006Article
- A SINE in the genome of the cephalochordate amphioxus is an Alu element.International journal of biological sciences · 2006Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 5 countries.
Funding
Abstract
The Hox gene cluster has been a key paradigm for a generation of developmental and evolutionary biologists. Since its discovery in the mid-1980's, the identification, genomic organization, expression, colinearity, and regulation of Hox genes have been immediate targets for study in any new model organism, and metazoan genome projects always refer to the structure of the particular Hox cluster(s). Since the early 1990's, it has been dogma that vertebrate Hox clusters are composed of thirteen paralogous groups. Nonetheless, we showed that in the otherwise prototypical cephalochordate amphioxus (Branchiostoma floridae), the Hox cluster contains a fourteenth Hox gene, and very recently, a 14(th) Hox paralogous group has been found in the coelacanth and the horn shark, suggesting that the amphioxus cluster was anticipating the finding of Hox 14 in some vertebrate lineages. In view of the pivotal place that amphioxus occupies in vertebrate evolution, we thought it of considerable interest to establish the limits of its Hox gene cluster, namely resolution of whether more Hox genes are present in the amphioxus cluster (e.g., Hox 15). Using two strategies, here we report the completion and characterization of the Hox gene content of the single amphioxus Hox cluster, which encompasses 650 kb from Hox1 to Evx. Our data have important implications for the primordial Hox gene cluster of chordates: the prototypical nature of the single amphioxus Hox cluster makes it unlikely that additional paralogous groups will be found in any chordate lineage. We suggest that 14 is the end.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.