ArticleBritish journal of pharmacology2005
Thrombin-induced glucose transport via Src-p38 MAPK pathway in vascular smooth muscle cells.
Article in British journal of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Thrombin Induces COX-2 and PGEMediators of inflammation · 2022Article
- Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification.Molecular therapy. Nucleic acids · 2020Article
- Targeting tyrosine kinases and autophagy in prostate cancer.Hormones & cancer · 2011Review
- Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Activation of the non-receptor tyrosine kinase cSrc in macrophage-rich atherosclerotic plaques of human carotid arteries.Acta histochemica et cytochemica · 2007Article
- Adrenaline increases glucose transport via a Rap1-p38MAPK pathway in rat vascular smooth muscle cells.British journal of pharmacology · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Thrombin is a mitogen for vascular smooth muscle cells (VSMC) and has been implicated in the development in atherosclerosis. However, little is known about the role of thrombin in glucose transport in VSMC. In this study, we examined the effect of thrombin on glucose uptake in rat A10 VSMC. We found that thrombin induced glucose uptake in a dose-dependent manner while hirudin, a potent thrombin inhibitor, prevented glucose uptake in the cells. PP2, a selective inhibitor of Src, prevented the thrombin-induced glucose uptake, but did not affect insulin-induced uptake. We also examined whether mitogen-activated protein kinase (MAPK) inhibitors influenced thrombin-induced glucose uptake. The p38 MAPK inhibitor (SB203580) inhibited thrombin-induced glucose uptake, but the MEK inhibitor (PD98059) did not. In contrast to thrombin, SB203580 did not affect insulin-induced glucose uptake. Furthermore, thrombin failed to translocate the insulin-sensitive glucose transporter GLUT4. These findings suggest that thrombin stimulates glucose transport via Src and subsequent p38 MAPK activation in VSMC.
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