ArticleNature biotechnology2005
Multiplexed detection of pathogen DNA with DNA-based fluorescence nanobarcodes.
Article in Nature biotechnology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
98 citing papers in PubMed, 515 citations in OpenAlex.
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- Highly spatial-temporal electrochemical profiling of molecules trafficking at a single mitochondrion in one living cell.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A light-efficient and versatile multiplexing method for snapshot spectral imaging.Scientific reports · 2024Article
- DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules.Bioactive materials · 2024Review
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- Microcavity- and Microlaser-Based Optical Barcoding: A Review of Encoding Techniques and Applications.ACS photonics · 2023Review
- Hierarchical DNA branch assembly-encoded fluorescent nanoladders for single-cell transcripts imaging.Nucleic acids research · 2023Article
- Detection of Trace Amounts of Water in Organic Solvents by DNA-Based Nanomechanical Sensors.Biosensors · 2022Article
- Application of nanotechnology in food: processing, preservation, packaging and safety assessment.Heliyon · 2022Review
- A highly sensitive bio-barcode immunoassay for multi-residue detection of organophosphate pesticides based on fluorescence anti-quenching.Journal of pharmaceutical analysis · 2022Article
- The Pivotal Role of Quantum Dots-Based Biomarkers Integrated with Ultra-Sensitive Probes for Multiplex Detection of Human Viral Infections.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Single-particle combinatorial multiplexed liposome fusion mediated by DNA.Nature chemistry · 2022Article
- Aptamers for Viral Detection and Inhibition.ACS infectious diseases · 2022Review
- A multiplexed circulating tumor DNA detection platform engineered from 3D-coded interlocked DNA rings.Bioactive materials · 2022Article
- Recent Advances in Surface Plasmon Resonance Sensors for Sensitive Optical Detection of Pathogens.Biosensors · 2022Review
- Smart Nucleic Acid Hydrogels with High Stimuli-Responsiveness in Biomedical Fields.International journal of molecular sciences · 2022Review
- Multiplexed structured illumination super-resolution imaging with lifetime-engineered upconversion nanoparticles.Nanoscale advances · 2021Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid, multiplexed, sensitive and specific molecular detection is of great demand in gene profiling, drug screening, clinical diagnostics and environmental analysis. One of the major challenges in multiplexed analysis is to identify each specific reaction with a distinct label or 'code'. Two encoding strategies are currently used: positional encoding, in which every potential reaction is preassigned a particular position on a solid-phase support such as a DNA microarray, and reaction encoding, where every possible reaction is uniquely tagged with a code that is most often optical or particle based. The micrometer size, polydispersity, complex fabrication process and nonbiocompatibility of current codes limit their usability. Here we demonstrate the synthesis of dendrimer-like DNA-based, fluorescence-intensity-coded nanobarcodes, which contain a built-in code and a probe for molecular recognition. Their application to multiplexed detection of the DNA of several pathogens is first shown using fluorescence microscopy and dot blotting, and further demonstrated using flow cytometry that resulted in detection that was sensitive (attomole) and rapid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.