ArticleNature biotechnology2005
Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes.
Article in Nature biotechnology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
117 citing papers in PubMed, 501 citations in OpenAlex.
- Review
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- Manipulating the Light Systemic Signal HY5 Greatly Improve Fruit Quality in Tomato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cell-Penetrating Peptide-Mediated Delivery of Gene-Silencing Nucleic Acids to the Invasive Common ReedPlants (Basel, Switzerland) · 2025Article
- A New Approach for CRISPR/Cas9 Editing and Selection of Pathogen-Resistant Plant Cells of Wine Grape cv. 'Merlot'.International journal of molecular sciences · 2024Article
- The transcriptional regulatory module CsHB5-CsbZIP44 positively regulates abscisic acid-mediated carotenoid biosynthesis in citrus (Citrus spp.).Plant biotechnology journal · 2024Article
- Application of Tryptophan and Methionine in Broccoli Seedlings Enhances Formation of Anticancer Compounds Sulforaphane and Indole-3-Carbinol and Promotes Growth.Foods (Basel, Switzerland) · 2024Article
- Light regulation of the biosynthesis of phenolics, terpenoids, and alkaloids in plants.Communications biology · 2023Review
- The potential of metabolomics in assessing global compositional changes resulting from the application of CRISPR/Cas9 technologies.Transgenic research · 2023Article
- Beyond green and red: unlocking the genetic orchestration of tomato fruit color and pigmentation.Functional & integrative genomics · 2023Review
- Tweaking the Small Non-Coding RNAs to Improve Desirable Traits in Plant.International journal of molecular sciences · 2023Review
- Genetics and breeding of phenolic content in tomato, eggplant and pepper fruits.Frontiers in plant science · 2023Review
- Nanovector-mediated exogenous delivery of dsRNA induces silencing of target genes in very young tomato flower buds.Nanoscale advances · 2022Article
- High-value pleiotropic genes for developing multiple stress-tolerant biofortified crops for 21st-century challenges.Heredity · 2022Article
- Applications of Genomic Tools in Plant Breeding: Crop Biofortification.International journal of molecular sciences · 2022Review
- Mining of Potential Gene Resources for Breeding Nutritionally Improved Maize.Plants (Basel, Switzerland) · 2022Review
- Fruit ripening: dynamics and integrated analysis of carotenoids and anthocyanins.BMC plant biology · 2022Review
- TeaHorticulture research · 2022Article
- Fruit nutritional composition, antioxidant and biochemical profiling of diverse tomatoFrontiers in plant science · 2022Article
- Map-Based Cloning and Characterization ofFrontiers in plant science · 2022Article
57 more citing papers are in PubMed but not listed here.
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13 authors at 5 institutions in 4 countries.
Funding
Abstract
Tomatoes are a principal dietary source of carotenoids and flavonoids, both of which are highly beneficial for human health. Overexpression of genes encoding biosynthetic enzymes or transcription factors have resulted in tomatoes with improved carotenoid or flavonoid content, but never with both. We attempted to increase tomato fruit nutritional value by suppressing an endogenous photomorphogenesis regulatory gene, DET1, using fruit-specific promoters combined with RNA interference (RNAi) technology. Molecular analysis indicated that DET1 transcripts were indeed specifically degraded in transgenic fruits. Both carotenoid and flavonoid contents were increased significantly, whereas other parameters of fruit quality were largely unchanged. These results demonstrate that manipulation of a plant regulatory gene can simultaneously influence the production of several phytonutrients generated from independent biosynthetic pathways, and provide a novel example of the use of organ-specific gene silencing to improve the nutritional value of plant-derived products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.