ArticleGenes and immunity2005
Genome-wide search for sarcoidosis susceptibility genes in African Americans.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06865274 (Multicenter Prospective Interventional Study to Evaluate the Frequency of FCGR3A Gene Polymorphisms in Patients With Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody Disease, and Multiple Sclerosis.), which is not on this map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Prospective Interventional Study to Evaluate the Frequency of FCGR3A Gene Polymorphisms in Patients With Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody Disease, and Multiple Sclerosis.
Who cites it
35 citing papers in PubMed, 108 citations in OpenAlex.
- Replication of genetic loci for sarcoidosis in US black women: data from the Black Women's Health Study.Human genetics · 2013Trial
- Neurosarcoidosis: a review from diagnosis and future perspectives.EClinicalMedicine · 2025Review
- Clinical Manifestations and Management of Fibrotic Pulmonary Sarcoidosis.Journal of clinical medicine · 2023Review
- Genetics of neurosarcoidosis.Journal of neuroimmunology · 2022Review
- Novel HumanFrontiers in immunology · 2022Article
- Sarcoidosis Epidemiology: Race Matters.Frontiers in immunology · 2020Review
- A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.Scientific reports · 2019Article
- Linking Race, Cancer Outcomes, and Tissue Repair.The American journal of pathology · 2018Review
- Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis.Scientific reports · 2017Article
- [Sarcoidosis : Dermatological view of a rare multisystem disease].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2017Review
- Identification of Jak-STAT signaling involvement in sarcoidosis severity via a novel microRNA-regulated peripheral blood mononuclear cell gene signature.Scientific reports · 2017Article
- FCGR3A and FCGR3B copy number variations are risk factors for sarcoidosis.Human genetics · 2016Article
- Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches.Clinics in chest medicine · 2015Review
- Blockade of the programmed death-1 pathway restores sarcoidosis CD4(+) T-cell proliferative capacity.American journal of respiratory and critical care medicine · 2014Article
- Carbon Nanotubes and Chronic Granulomatous Disease.Nanomaterials (Basel, Switzerland) · 2014Article
- Reproductive and hormonal factors in relation to incidence of sarcoidosis in US Black women: The Black Women's Health Study.American journal of epidemiology · 2012Article
- Article
- A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans.Genes and immunity · 2011Article
- A concise review of pulmonary sarcoidosis.American journal of respiratory and critical care medicine · 2011Review
- Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.Molecular vision · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 13 institutions in 1 country.
Funding
Abstract
Sarcoidosis, a systemic granulomatous disease of unknown etiology, likely results from an environmental insult in a genetically susceptible host. In the US, African Americans are more commonly affected with sarcoidosis and suffer greater morbidity than Caucasians. We searched for sarcoidosis susceptibility loci by conducting a genome-wide, sib pair multipoint linkage analysis in 229 African-American families ascertained through two or more sibs with a history of sarcoidosis. Using the Haseman-Elston regression technique, linkage peaks with P-values less than 0.05 were identified on chromosomes 1p22, 2p25, 5p15-13, 5q11, 5q35, 9q34, 11p15 and 20q13 with the most prominent peak at D5S2500 on chromosome 5q11 (P=0.0005). We found agreement for linkage with the previously reported genome scan of a German population at chromosomes 1p and 9q. Based on the multiple suggestive regions for linkage found in our study population, it is likely that more than one gene influences sarcoidosis susceptibility in African Americans. Fine mapping of the linked regions, particularly on chromosome 5q, should help to refine linkage signals and guide further sarcoidosis candidate gene investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.