Evidence map›Paper›PMID 15951527›Full record

ReviewGut2005

Human pancreatic exocrine response to nutrients in health and disease.

J Keller, P Layer

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05082051 (A 3-part, Phase 1a/1b, First-in-human, Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Oral CDX-7108 in Healthy Adult Subjects and to Evaluate Proof-of-concept Via Pharmacodynamics of a Single Dose of Oral CDX-7108 in Subjects with Exocrine Pancreatic Insufficiency), which is not on this map. Cited by 106 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05082051 phase1completednot on this mapstarted 2021, after this paper: background citation

A 3-part, Phase 1a/1b, First-in-human, Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Oral CDX-7108 in Healthy Adult Subjects and to Evaluate Proof-of-concept Via Pharmacodynamics of a Single Dose of Oral CDX-7108 in Subjects with Exocrine Pancreatic Insufficiency

TypeinterventionalSponsorSociété des Produits Nestlé (SPN)Ran2021 to 2023Enrolled54ConditionsExocrine Pancreatic InsufficiencyArmsPart A, Part B, Part C
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. European guideline on indications, performance and clinical impact ofUnited European gastroenterology journal · 2021
    Guideline
  5. Pooled it
  6. Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency: Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018
    Pooled it
  7. Pooled it
  8. Guideline
  9. Pancreatic adenocarcinoma.Journal of the National Comprehensive Cancer Network : JNCCN · 2010
    Guideline
  10. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
    Guideline
  11. Trial
  12. Trial
  13. Unique causes of exocrine pancreatic insufficiency: When to consider pancreatic enzyme supplementation: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  14. Clinical Practice Update on the Evaluation, Diagnosis, and Management of Pancreatic Exocrine Insufficiency: Expert Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

J KellerIsraelitic Hospital, University of Hamburg, Orchideenstieg 14, D-22297 Hamburg, Germany. keller@ik-h.de
P Layer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DietNutritional Physiological PhenomenaAgingBicarbonatesBile Acids and SaltsDiabetes MellitusDietary CarbohydratesDietary ProteinsDigestionEnzymesEnzyme TherapyGastrointestinal DiseasesHealthHumansHydrogen-Ion ConcentrationLipidsBicarbonatesBile Acids and SaltsDietary CarbohydratesDietary ProteinsEnzymesLipids

Identifiers

PMID15951527
PMCPMC1867805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.