Trial reportHeart (British Cardiac Society)2006
Favourable long term prognosis in stable angina pectoris: an extended follow up of the angina prognosis study in Stockholm (APSIS).
Trial report in Heart (British Cardiac Society), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Beta-blockers for hypertension.The Cochrane database of systematic reviews · 2017Pooled it
- Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).The American journal of cardiology · 2016Trial
- Mortality implications of angina and blood pressure in hypertensive patients with coronary artery disease: New data from extended follow-up of the International Verapamil/Trandolapril Study (INVEST).Clinical cardiology · 2013Trial
- Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial.European heart journal · 2009Trial
- Clinical value of a comprehensive clinical- and echocardiography-based risk score on predicting cardiovascular outcomes in ischemic heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Long-term prognosis of unheralded myocardial infarction vs chronic angina; role of sex and coronary atherosclerosis burden.BMC cardiovascular disorders · 2018Article
- Consensus Document ANMCO/ANCE/ARCA/GICR-IACPR/GISE/SICOA: Long-term Antiplatelet Therapy in Patients with Coronary Artery Disease.European heart journal supplements : journal of the European Society of Cardiology · 2018Article
- ANMCO/GICR-IACPR/SICI-GISE Consensus Document: the clinical management of chronic ischaemic cardiomyopathy.European heart journal supplements : journal of the European Society of Cardiology · 2017Article
- Review
- Medical management of chronic stable angina.Australian prescriber · 2015Review
- Observational
- Persistent angina pectoris in ischaemic cardiomyopathy: increased rehospitalization and major adverse cardiac events.European journal of heart failure · 2014Article
- Heart failure with preserved ejection fraction: comparison of patients with and without angina pectoris (from the Duke Databank for Cardiovascular Disease).Journal of the American College of Cardiology · 2014Article
- Prognostic value of cardiovascular disease status: the Leiden 85-plus study.Age (Dordrecht, Netherlands) · 2013Article
- Short-term effects of ivabradine in patients with chronic stable ischemic heart disease.Heart views : the official journal of the Gulf Heart Association · 2013Article
- Therapy for stable angina in women.P & T : a peer-reviewed journal for formulary management · 2012Article
- Symptom clusters and health-related quality of life in people with chronic stable angina.Journal of advanced nursing · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the long term prognosis of patients with stable angina pectoris.
designRegistry based follow up (median 9.1 years) of patients participating in the APSIS (angina prognosis study in Stockholm), which was a double blind, single centre trial of antianginal drug treatment. PATIENTS: 809 patients (31% women) with stable angina pectoris < 70 (mean (SD) 59 (7) years at inclusion) and an age and sex matched reference population from the same catchment area.
interventionsDouble blind treatment with metoprolol or verapamil during 3.4 years (median), followed by referral for usual care with open treatment.
main outcome measuresCardiovascular (CV) death and non-fatal myocardial infarction (MI) in the APSIS cohort and total mortality in comparison with reference subjects.
results123 patients died (41 MI, 36 other CV causes) and 72 had non-fatal MI. Mortality (19% v 6%, p < 0.001) and fatal MI (6.6% v 1.6%, p < 0.001) were increased among male compared with female patients. Diabetes, previous MI, hypertension, and male sex independently predicted CV mortality (p < 0.001). Diabetes greatly increased the risk in a small subgroup of female patients. Male patients had higher mortality than men in the reference population during the first three years (cumulative absolute difference 3.8%) but apparently not thereafter. Female patients had similar mortality to women in the reference population throughout the 9.1 years of observation.
conclusionsFemale patients with stable angina had similar mortality to matched female reference subjects but male patients had an increased risk. Diabetes, previous MI, hypertension, and male sex were strong risk factors for CV death or MI.
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