ArticleBiophysical journal2005
Effect of salicylate on the elasticity, bending stiffness, and strength of SOPC membranes.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
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- Acetaminophen Interactions with Phospholipid Vesicles Induced Changes in Morphology and Lipid Dynamics.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- EPA and DHA differentially modulate membrane elasticity in the presence of cholesterol.Biophysical journal · 2021Article
- Extracellular Vesicles From Auditory Cells as Nanocarriers for Anti-inflammatory Drugs and Pro-resolving Mediators.Frontiers in cellular neuroscience · 2019Article
- Effect of Statins on the Nanomechanical Properties of Supported Lipid Bilayers.Biophysical journal · 2016Article
- The chloride-channel blocker 9-anthracenecarboxylic acid reduces the nonlinear capacitance of prestin-associated charge movement.The European journal of neuroscience · 2016Article
- Effects of salicylate on sound-evoked outer hair cell stereocilia deflections.Pflugers Archiv : European journal of physiology · 2015Article
- The shape/morphology balance: a study of stealth liposomes via fractal analysis and drug encapsulation.Pharmaceutical research · 2013Article
- Small-molecule photostabilizing agents are modifiers of lipid bilayer properties.Biophysical journal · 2013Article
- Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation.Faraday discussions · 2013Article
- Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphatidylcholine.Biochimica et biophysica acta · 2012Article
- A microfabricated magnetic force transducer-microaspiration system for studying membrane mechanics.Physical biology · 2011Article
- Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery.The Journal of general physiology · 2011Article
- Interaction of salicylate and a terpenoid plant extract with model membranes: reconciling experiments and simulations.Biophysical journal · 2010Article
- The anti-inflammatory drug indomethacin alters nanoclustering in synthetic and cell plasma membranes.The Journal of biological chemistry · 2010Article
- Screening for small molecules' bilayer-modifying potential using a gramicidin-based fluorescence assay.Assay and drug development technologies · 2010Article
- Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes.Journal of the Royal Society, Interface · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salicylate is a small amphiphilic molecule which has diverse effects on membranes and membrane-mediated processes. We have utilized micropipette aspiration of giant unilamellar vesicles to determine salicylate's effects on lecithin membrane elasticity, bending rigidity, and strength. Salicylate effectively reduces the apparent area compressibility modulus and bending modulus of membranes in a dose-dependent manner at concentrations above 1 mM, but does not greatly alter the actual elastic compressibility modulus at the maximal tested concentration of 10 mM. The effect of salicylate on membrane strength was investigated using dynamic tension spectroscopy, which revealed that salicylate increases the frequency of spontaneous defect formation and lowers the energy barrier for unstable hole formation. The mechanical and dynamic tension experiments are consistent and support a picture in which salicylate disrupts membrane stability by decreasing membrane stiffness and membrane thickness. The tension-dependent partitioning of salicylate was utilized to calculate the molecular volume of salicylate in the membrane. The free energy of transfer for salicylate insertion into the membrane and the corresponding partition coefficient were also estimated, and indicated favorable salicylate-membrane interactions. The mechanical changes induced by salicylate may affect several biological processes, especially those associated with membrane curvature and permeability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.