ReviewCurrent opinion in immunology2005
Vaccinology at the beginning of the 21st century.
Review in Current opinion in immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Review
- Computational Epitope Prediction and Design for Antibody Development and Detection.Methods in molecular biology (Clifton, N.J.) · 2023Article
- MMV-db: vaccinomics and RNA-based therapeutics database for infectious hemorrhagic fever-causing mammarenaviruses.Database : the journal of biological databases and curation · 2021Article
- Review
- Chitosan and chitosan nanoparticles as adjuvant in local Rift Valley Fever inactivated vaccine.3 Biotech · 2020Article
- Systems vaccinology and big data in the vaccine development chain.Immunology · 2019Review
- Properties and applications of nanoparticle/microparticle conveyors with adjuvant characteristics suitable for oral vaccination.International journal of nanomedicine · 2018Review
- Zymosan A enhances humoral immune responses to soluble protein in chickens.The Journal of veterinary medical science · 2017Article
- [Innovations in vaccinology: challenge and opportunities for Africa].The Pan African medical journal · 2017Article
- A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation.Journal of materials chemistry. B · 2016Article
- Article
- Carbon nanotubes as vaccine scaffolds.Advanced drug delivery reviews · 2013Review
- Laser vaccine adjuvant for cutaneous immunization.Expert review of vaccines · 2011Article
- Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant.PloS one · 2011Article
- The Role of Immunogenicity in Cardiovascular Disease.World heart journal · 2011Article
- Inflammatory and autoimmune reactions in atherosclerosis and vaccine design informatics.Journal of biomedicine & biotechnology · 2010Review
- Article
- How B cells shape the immune response against Mycobacterium tuberculosis.European journal of immunology · 2009Review
- Profiling antibody responses by multiparametric analysis of primary B cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans.BMC genomics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Today, the main challenges for vaccinologists include improving vaccines against as yet undefeated pathogens, rapid identification and response to emerging diseases and successful intervention in chronic diseases in which ongoing immune responses are insufficient. Reverse genetics and reverse vaccinology are now used to generate rapidly new vaccine strains and to mine whole genomes in the search for promising antigens. The rational design of adjuvants has become possible as a result of the discovery of the receptors that recognize microbial patterns and lead to dendritic cell activation. Antigen-loaded dendritic cells, DNA in naked, formulated or viral form, and other delivery systems are used to maximize immune responses. Although work on the 'easy' vaccines has already been completed, it is hoped that a combination of conceptual and technical innovation will enable the development of more complex and sophisticated vaccines in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.