Evidence map›Paper›PMID 15950229›Full record

ArticleInternational journal for parasitology2005

In vivo imaging of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs.

Stephen J Davies, Steven J Smith, K C Lim, Hongbing Zhang, Anthony F Purchio, James H McKerrow, David B West

Open access · greenAbstract read
In one paragraph

Article in International journal for parasitology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. The Role of MIF on Eosinophil Biology and Eosinophilic Inflammation.Clinical reviews in allergy & immunology · 2020
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Advances in bioluminescence imaging of live animal models.Current opinion in biotechnology · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stephen J DaviesDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Room B4104, Bethesda, MD 20814-4799, USA. sdavies@usuhs.mil
Steven J Smith
K C Lim
Hongbing Zhang
Anthony F Purchio
James H McKerrow
David B West
University of California, San Francisco · USUniformed Services University of the Health Sciences · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Immune modualtion of schistosome developmentK22AI053054 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI DAVIES, STEPHEN J · 2004 to 2005
$267k
ADAPTIVE IMMUNITY SUPPORTS SCHISTOSOME DEVELOPMENTF32AI010424 · NIAID · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI DAVIES, STEPHEN J · 2000 to 2002
$148k
NIAID NIH HHS F32 AI010424NIAID NIH HHS F32 AI10424NIAID NIH HHS K22 AI053054NIAID NIH HHS K22 AI53054NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK26743
6 · The paper itself

Abstract

Using a sensitive transgenic reporter mouse system and in vivo biophotonic imaging techniques, we present a dynamic analysis of eosinophil responses to schistosome infection. Use of this methodology provided previously unattainable detail on the spatial and temporal distribution of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs. Dramatic hepatic and intestinal eosinophilia in response to the deposition of schistosome eggs, with accompanying eosinopoiesis in the bone marrow, was observed between weeks 8 and 10 p.i., with subsequent downregulation evident by week 11. Contrary to expectations, we also demonstrate that schistosome parasites themselves induce significant intestinal eosinophilia and eosinopoiesis in the bone marrow at very early stages during prepatent infection.

Indexed as

AnimalsDisease Models, AnimalDown-RegulationEosinophiliaEosinophilsIntestinal Diseases, ParasiticIntestinesLiverLiver Diseases, ParasiticLuciferasesLuminescenceMiceMice, TransgenicParasite Egg CountSchistosoma mansoniSchistosomiasis mansoniLuciferases

Identifiers

PMID15950229
PMCPMC2891237
OpenAlexW2045668811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.