ArticleBritish journal of clinical pharmacology2005
Acute drug prescribing to children on chronic antiepilepsy therapy and the potential for adverse drug interactions in primary care.
Article in British journal of clinical pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Functionalized monolithic columns: Recent advancements and their applications for high-efficiency separation and enrichment in food and medicine.Frontiers in chemistry · 2022Review
- Variation of the prevalence of pediatric polypharmacy: A scoping review.Pharmacoepidemiology and drug safety · 2019Article
- Article
- Defining pediatric polypharmacy: A scoping review.PloS one · 2018Article
- Off-label drug use in hospitalized children: a prospective observational study at Gondar University Referral Hospital, Northwestern Ethiopia.Pharmacology research & perspectives · 2017Article
- Learning Lessons from Adverse Drug Reactions in Children.Children (Basel, Switzerland) · 2016Review
- Off-label medicine use in pediatric inpatients: a prospective observational study at a tertiary care hospital in India.International journal of pediatrics · 2014Article
- A high-speed drug interaction search system for ease of use in the clinical environment.Journal of medical systems · 2012Article
- Antiepileptic drug monotherapy: the initial approach in epilepsy management.Current neuropharmacology · 2009Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the extent of acute coprescribing in primary care to children on chronic antiepileptic therapy, which could give rise to potentially harmful drug-drug interactions.
designAcute coprescribing to children on chronic antiepileptic drug therapy in primary care was assessed in 178 324 children aged 0-17 years for the year 1 November 1999 to 31 October 2000. Computerized prescribing data were retrieved from 161 representative general practices in Scotland.
settingOne hundred and sixty-one general practices throughout Scotland.
resultsDuring the study year 723 (0.41%) children chronically prescribed antiepileptic therapy were identified. Fourteen antiepileptic agents were prescribed, with carbamazepine, sodium valproate and lamotrigine accounting for 80% of the total. During the year children on chronic antiepileptic therapy were prescribed 4895 acute coprescriptions for 269 different medicines. The average number of acute coprescriptions for non-epileptic drug therapy were eight, 11, six, and six for the 0-1, 2-4, 5-11, and 12-17-year-olds, respectively. Of these acute coprescriptions 72 (1.5%) prescribed to 22 (3.0%) children were identified as a potential source of clinically serious interactions. The age-adjusted prevalence rates for potentially serious coprescribing were 86, 26, 22, and 33/1000 children chronically prescribed antiepileptic therapy in the 0-1, 2-4, 5-11, and 12-17-year-old age groups, respectively. The drugs most commonly coprescribed which could give rise to such interactions were antacids, erythromycin, ciprofloxacin, theophylline and the low-dose oral contraceptive. For 10 (45.5%0 of the 20 children identified at risk of a potentially clinically serious adverse drug interaction, the acute coprescription was prescribed off label because of age or specific contraindication/warning.
conclusionsIn primary care, 3.0% of children on chronic antiepileptic therapy are coprescribed therapeutic agents, which could give rise to clinically serious drug-drug interactions.
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